Pertuzumab numerically improved IDFS in all subgroups, greatest in HER2 FISH-low/ER-positive tumors. These exploratory findings are hypothesis-generating and support prospective validation of biomarker-guided strategies.

3 days ago

Clinical • Journal

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)

HER-2 positive • ER positive • HER-2 amplification • HER-2 expression • ER negative

Herceptin (trastuzumab) • Perjeta (pertuzumab)

Clinically actionable alterations in Indian breast cancer patients derived through whole transcriptome sequencing. (PubMed, Indian J Med Res)

Fusion transcript analysis identified 91 recurrent fusions, including novel partners with ERBB2, MED1, and CDK12, suggesting the possibility of unique molecular events. Interpretation and conclusions This study demonstrates that Indian breast cancer patients exhibit molecular subtypes and actionable mutations comparable to Caucasian cohorts.

3 days ago

Review • Journal • BRCA Biomarker

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • FGFR2 (Fibroblast growth factor receptor 2) • PTEN (Phosphatase and tensin homolog) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CDK12 (Cyclin dependent kinase 12) • MBD4 (Methyl-CpG Binding Domain 4, DNA Glycosylase)

HER-2 positive • TP53 mutation • BRCA2 mutation • ER positive • BRCA1 mutation • PIK3CA mutation • HER-2 expression • PTEN mutation • FGFR2 mutation • AKT1 mutation

Prosigna™ Breast Cancer Prognostic Gene Signature Assay

A Phase Ib/II Study Evaluating Injectable ALK-N001 in Patients With Advanced Solid Tumors (clinicaltrials.gov)

P1/2, N=190, Not yet recruiting, Zhejiang Anglikang Pharmaceutical Co., Ltd.

4 days ago

New P1/2 trial

HER-2 (Human epidermal growth factor receptor 2)

HER-2 expression

Anti-cancer effect of a novel photodynamic therapy using glucose-linked chlorin e6 conjugated trastuzumab for HER2-positive gastrointestinal cancers. (PubMed, PLoS One)

Evaluation of cell death using the WST-8 assay also demonstrated a significantly higher cytotoxic effect of G-Ce6-trastuzumab in HER2-high-expression cells compared with conventional PS G-Ce6. Thereby, G-Ce6-trastuzumab may be an excellent novel PS for PDT because of its strong selectivity for HER2-high-expression cells.

4 days ago

Journal

HER-2 (Human epidermal growth factor receptor 2)

HER-2 positive • HER-2 overexpression • HER-2 expression • HER-2 underexpression

Herceptin (trastuzumab)

Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced HER2-expressing Rectal Cance (clinicaltrials.gov)

P2, N=29, Not yet recruiting, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

4 days ago

New P2 trial

HER-2 (Human epidermal growth factor receptor 2)

HER-2 expression

Tyvyt (sintilimab) • capecitabine • Aidixi (disitamab vedotin)

Final results of the INFINITY precision oncology registry: non-standard targeted treatments in patients with advanced cancers in routine care. (PubMed, ESMO Real World Data Digit Oncol)

In a tumor-agnostic approach, biomarker-informed NSTT was associated with clinical benefit in 31.7% of the patients, with checkpoint inhibitors being the most common treatment. The INFINITY project demonstrates the feasibility of a large-scale precision oncology project in a community oncology setting and thus supports the implementation of precision oncology into routine clinical practice in Germany.

5 days ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene)

BRAF mutation • HER-2 mutation • HER-2 expression

Study to Evaluate Efficacy & Safety of Afuresertib Plus Fulvestrant in Patients With Locally Advanced or Metastatic HR+/HER2- Breast Cancer (clinicaltrials.gov)

P3, N=256, Active, not recruiting, Laekna Limited | Recruiting --> Active, not recruiting

5 days ago

Enrollment closed

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog) • AKT1 (V-akt murine thymoma viral oncogene homolog 1)

HER-2 negative • PIK3CA mutation • HER-2 expression • PTEN mutation • ESR1 mutation

fulvestrant • afuresertib (LAE002)

Real-World Evidence of Immunohistochemical Discordance in Breast Cancer Brain Metastases. (PubMed, Clin Breast Cancer)

A notably high frequency of IHC discordance between primary BC and BCBM was observed, exceeding rates previously reported. Recognizing this heterogeneity may guide more personalized treatment approaches.

6 days ago

Journal • HEOR • Real-world evidence

HER-2 (Human epidermal growth factor receptor 2) • PGR (Progesterone receptor)

HER-2 positive • HER-2 expression

A Simple and Cost-Effective Method for Generating Spheroids From Triple-Negative Breast Cancer Cell Line (MDA-MB-231). (PubMed, Bio Protoc)

• Generates measurable spheroids within 96 h using only basic cell culture equipment and an orbital shaker. • Provides a clear workflow from spheroid formation to quantitative size analysis, using freely available (ImageJ) and widely used (GraphPad Prism) software.

6 days ago

Preclinical • Journal • HEOR • Cost-effectiveness

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)

HER-2 expression

Survival Disparities in Hispanic/Latino Patients With Gastric Cancer at a High-Volume Cancer Center. (PubMed, J Surg Res)

Despite treatment at a high-volume comprehensive cancer center, H/L ethnicity independently predicts worse survival, suggesting that factors beyond hospital quality contribute to disparities. Identifying and addressing social barriers are essential steps toward improving outcomes for these high-risk populations.

6 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1)

PD-L1 expression • HER-2 positive • HER-2 expression