P2, N=0, Withdrawn, Assistance Publique - Hôpitaux de Paris | N=110 --> 0 | Recruiting --> Withdrawn

P2, N=75, Not yet recruiting, University of Alabama at Birmingham | Initiation date: Apr 2026 --> Jul 2026

Decitabine restores gasdermin E expression to couple oxidative stress with caspase-3-mediated pyroptosis, while chlorogenic acid repolarizes tumor-associated macrophages toward a pro-inflammatory phenotype. This coordinated multimodal cell-death cascade establishes a self-amplifying immunogenic circuit that suppresses tumor growth, sensitizes CRC to ICB, and elicits systemic antitumor immunity.

Patient was managed acutely with calcitonin and was started on prednisone and hydroxychloroquine. The co-occurrence of both MEN 2A and sarcoidosis is rare, adding an unexpected layer of complexity to the diagnosis. The rarity of sarcoidosis co-occurring with MEN 2A highlights the importance of considering a broad differential diagnosis, even in patients with known genetic syndromes, to ensure accurate management.

P2, N=48, Active, not recruiting, medac GmbH | Recruiting --> Active, not recruiting

P1/2, N=12, Not yet recruiting, Annexin Pharmaceuticals AB (publ)

P1, N=50, Not yet recruiting, LyncBio Therapeutics Co., Ltd.

P1/2, N=16, Terminated, Takeda | Trial completion date: May 2026 --> Nov 2025 | Active, not recruiting --> Terminated; Sponsor decision (No safety concern)

aureum was enriched in ferulic acid, rutin, chlorogenic acid, and p-coumaric acid, whereas A. mexicana contained veratric acid, luteolin, and apigenin...These findings highlight a clear relationship between phytochemical composition and biological activity, indicating that these medicinal plants may serve as promising sources of multitarget phytotherapeutic agents. Further in vivo studies and bioactive compound isolation are required to validate their therapeutic potential.

The therapeutic potential of SHCZF was evaluated in alpha-naphthylisothiocyanate (ANIT)-induced IC rat model, with ursodeoxycholic acid (UDCA) used as positive control...Importantly, GW6471 altered the regulatory effects of SHCZF on MKK4/JNK pathway and bile acid homeostasis. SHCZF improves IC by regulating PPARα-mediated bile acid homeostasis and MKK4/JNK pathway.

P2, N=12, Not yet recruiting, Cellenkos, Inc.