P4, N=14, Active, not recruiting, University of California, Davis | Recruiting --> Active, not recruiting | N=50 --> 14 | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026

These findings collectively indicate that compound 5k exerts synergistic anti-CRC efficacy by triggering ferroptosis and activating antitumor immunity. Thus, compound 5k holds considerable promise as a lead ferroptosis inducer for the development of novel CRC therapeutic strategies.

P=N/A, N=96, Not yet recruiting, Assiut University

The patient was managed with corticosteroids, mycophenolate mofetil (MMF), and intravenous immunoglobulin G (IVIG), but later developed supraventricular tachycardia and deep vein thrombosis. This report emphasizes the need to enhance recognition of immune-related toxicities within non-oncology specialties to support prompt interdisciplinary collaboration and appropriate patient management. Additionally, patients can develop myocarditis-related complications even when clinically stable or near the end of treatment, underscoring the need for close and ongoing monitoring.

P=N/A, N=224, Recruiting, The First Affiliated Hospital of Soochow University

In addition, J2H-1802 significantly reduced serum tumor necrosis factor-α (TNF-α) levels and suppressed pro-inflammatory cytokine expression, including IL-1β, IL-6, IL-17, and TNF-α, in psoriatic skin. J2H-1802 alleviates both local and systemic inflammatory features of psoriasis, suggesting its potential as a therapeutic candidate for targeting IL-23/Th17-mediated inflammatory pathways.

P=N/A, N=100, Not yet recruiting, Federal University of Maranhao

Fibroblast-derived PAD2 can citrullinate extracellular matrix proteins (ECMPs), whereas the citrullination status of ECMPs reciprocally influences the behaviour of fibroblasts...PAD2 maintains the expression of Podoplanin and Tumor necrosis factor receptor superfamily member 1B (TNFRSF1b) in fibroblasts across multiple organs but promotes basal and TNFα-induced IL-6 expression in lung and synovial fibroblasts. These results suggest a novel pathogenic role for fibroblast-derived PAD2 in RA and offer a plausible explanation for the unique tissue tropism of RA.

Nearly half of patients developing ir-hepatitis had an inadequate response to steroids and needed MMF as a secondary immunosuppressant. Patients with mixed DILI were more likely to respond to steroids, while alcohol consumption was associated with inadequate steroid response. Immune analyses showed high T cell infiltration in the liver among patients with ir-hepatitis.

P4, N=100, Recruiting, Oslo University Hospital HF | Not yet recruiting --> Recruiting

P4, N=27, Completed, Oslo University Hospital HF | Not yet recruiting --> Completed

P3, N=21, Active, not recruiting, Dartmouth-Hitchcock Medical Center | Trial completion date: Sep 2025 --> Oct 2026