Kaposi Sarcoma

We characterize KHDRBS3 as a major host factor that is critical for KSHV lytic replication and uncover its key role in KSHV lytic gene transcription. Our results highlight a pivotal role for the miR-31-5p/KHDRBS3 axis in modulating KSHV reactivation and provide insights into gene-expression regulation of lytic KSHV.

Bacterial cellulitis was the most common dermatological condition overall, while oral candidiasis was the most common condition in those with advanced HIV infection. Further work is needed to better characterize the profile of skin disease in PLHIV, including in larger prospective cohorts and outpatient settings.

P1, N=15, Active, not recruiting, Imperial College London | Recruiting --> Active, not recruiting | Trial completion date: Apr 2026 --> Dec 2026 | Trial primary completion date: Apr 2026 --> Jul 2026

Hence, by splicing factors interactions, ALT interferes with host gene expression. Our results uncover a novel mechanism that shifts gene expression from the host to the virus late during the viral replication cycle to efficiently produce progeny virus and potentially antagonize host immune defenses.

P=N/A, N=30, Recruiting, Washington University School of Medicine | N=20 --> 30 | Trial completion date: May 2026 --> Jul 2028 | Trial primary completion date: May 2026 --> Jul 2028

These host-virus interaction events were also observed in the infection of another oncogenic gamma-herpesvirus Epstein-Barr virus (EBV). Overall, our results highlighted a new strategy for human gamma-herpesviruses to counteract host antiviral factors and promote their lytic replication by manipulating host m5C RNA methylation.

This report contributes to the limited body of literature on HHV-8-associated Kapsoi sarcoma in the setting of multicentric Castleman disease in HIV-negative patients. It emphasizes the importance of recognizing angiomatous subtype of Kaposi sarcoma with involvement of unusual anatomical sites.

P1, N=62, Not yet recruiting, Novartis Pharma AG | N=27 --> 62

P=N/A, N=300, Not yet recruiting, Washington University School of Medicine | N=100 --> 300

Hence, there is a dire need to introduce new medicinal plant-based therapeutic approaches against oncovirus. This review analyses the molecular pathways of viral oncogenesis critically and discusses the clinical translation and a promising future potential of phytochemicals derived from medicinal plants like Phyllanthus emblica, Datura stramonium, Cannabis sativa, Andrographis paniculata, Aegle marmelos, Calotropis procera, and Prosopis cineraria proven to have bioactive compounds functioning as antivirals, immune-modulator, pro-apoptotic, and cell cycle regulatory effects in the preclinical models along with multi-targets.

P2, N=55, Recruiting, National Cancer Institute (NCI) | Not yet recruiting --> Recruiting

Notably, we found that PRC2-mediated heterochromatin inhibits the HIF-1α-mediated upregulation of lytic genes as chromatinization of the KSHV genome progresses during infection. Our findings offer a deeper understanding of how epigenetic regulation intersects with host stress responses to influence viral pathogenesis.