KIT expression

Mutation-specific NPM1 IHC is a valuable tool for a rapid assessment of residual morphologic and molecular disease in mid- and postinduction NPM1mut AML.

P-TNTs, which are tightly associated in situ with endothelial-pericyte combined sprouts, appear to play a dual role during vessel collateralization by bridging the gap between distant vessels and guiding vascular outgrowth. The complementary cellular distribution of c-KIT and SCF observed in endothelial cells and pericytes suggests that both endothelial autocrine/paracrine SCF/c-KIT signaling and pericyte-derived paracrine/juxtacrine SCF cues may contribute to the pericyte-driven mode of vessel branching. Similar observations in GB samples further suggest a potential involvement of pericytes and their P-TNTs in tumor vascularization, although sprouting endothelial cells displayed distinct subcellular patterns of c-KIT expression in fetal versus GB tissues.

This study reveals that METTL3 facilitates BCa progression via MTA1-dependent partial activation of the IGF2BP3-PI3K/AKT axis, suggesting a potential therapeutic target.

Additionally, ERα expression was higher in the neutralized control dogs than in the intact controls, with no differences detected in the MCT dogs. These findings suggest that reproductive status is associated with differential regulation of molecular pathways involved in canine MCT biology.

Long-term organ culture recapitulates key molecular features of fibroids and reveals tissue-specific mechanisms governing stem cell activation and differentiation. These findings identify potential therapeutic opportunities and establish long-term organ culture as a robust, physiologically relevant platform for investigating normal and tumor biology.

KLF16, as a transcription factor, upregulates HSPB1 expression and promotes HCC resistance to Sora by inhibiting ferroptosis. KLF16 may be a potential therapeutic target to overcome Sora resistance in HCC.

P2, N=38, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2026 --> Mar 2027

Our results demonstrate that the inclusion of growth factors, such as GDNF and BMP-4, along with conditioned media and an "indirect co-culture using mesh" system utilizing meshes with SSCs, significantly enhances SSC proliferation and differentiation. The optimized conditions media provided by hAMSCs offer a superior feeder compared to traditional "indirect co-culture using mesh" systems for promoting both the proliferation and differentiation of SSCs.

Fosb drives SMC ferroptosis and inflammatory phenotypic switching, via NF-κB pathway activation, thereby reinforcing AAA progression. Targeting Fosb or the ferroptosis pathway may provide new therapeutic strategies for AAA treatment.

Prognosis in TETs relies primarily on histology and staging, whereas molecular and immunological biomarkers represent emerging tools for risk stratification and treatment selection. Multiparametric models integrating clinical, pathological, and molecular data may pave the way for precision oncology in TETs.

CD5 and CD117 are the best markers for TC. While the addition of other markers (i.e., BAP1 loss, MTAP loss and CDKN2A deletion) might be useful in cases negative for CD5 and CD117, rare cases of type B3 thymoma might harbor these alterations.

IGF2BP3 knockdown increased ovarian cancer sensitivity to sorafenib. This study confirmed that IGF2BP3 knockdown inhibited ovarian cancer cell malignancy, promoted ferroptosis and inhibited autophagy-mediated EMC2 degradation, and verified that IGF2BP3 knockdown increased the sensitivity to sorafenib in ovarian cancer mice.