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    DRUG:

    lomustine

    i
    Other names: CCNU
    Company:
    Generic mfg.
    Drug class:
    Alkylating agent
    Related drugs:
    3d
    ImproveCodel: A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas). (clinicaltrials.gov)
    P3, N=406, Recruiting, University Hospital Heidelberg | Trial completion date: Mar 2031 --> Mar 2033 | Trial primary completion date: Mar 2031 --> Mar 2033
    Trial completion date • Trial primary completion date • HEOR
    |
    temozolomide • vincristine • lomustine • Matulane (procarbazine hydrochloride)
    4d
    NRG-BN011: Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma (clinicaltrials.gov)
    P3, N=306, Suspended, NRG Oncology | Recruiting --> Suspended
    Trial suspension
    |
    IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • MGMT (6-O-methylguanine-DNA methyltransferase)
    |
    MGMT promoter methylation • IDH1 R132
    |
    temozolomide • lomustine
    11d
    Case Report: Primary intestinal histiocytic sarcoma in a cat. (PubMed, Front Vet Sci)
    The patient underwent surgical excision via enterectomy, followed by adjuvant lomustine chemotherapy, achieving complete remission. Despite transient chemotherapy-induced myelosuppression, the cat remains alive and disease-free 2 years after diagnosis. This case highlights the importance of combining imaging, histopathology, and IHC when diagnosing feline intestinal masses.
    Journal
    |
    KIT (KIT proto-oncogene, receptor tyrosine kinase) • IRF4 (Interferon regulatory factor 4) • MSR1 (Macrophage Scavenger Receptor 1)
    |
    CD20 positive
    |
    lomustine
    1m
    Comparison of Diagnostic Utilities in a Canine Retrobulbar Large B-Cell Lymphoma With Multifocal Involvement. (PubMed, Vet Med Sci)
    Chemotherapy with l-asparaginase, vincristine, cyclophosphamide, doxorubicin and prednisone was initiated; however, neurological symptoms developed after the first cycle. Subsequent cerebrospinal fluid cytology and flow cytometry suggested central nervous system involvement in the lymphoma, and the dog was euthanized owing to disease progression despite the addition of lomustine. To our knowledge, this is the first report of bilateral retrobulbar large B-cell lymphoma with multifocal involvement in a dog. A comprehensive assessment of diagnostic modalities is essential to diagnose extranodal lymphoma and assess extranodal involvement.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD34 (CD34 molecule) • CD5 (CD5 Molecule) • CD79A (CD79a Molecule)
    |
    doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • lomustine
    2ms
    Treatment strategies and innovation for recurrent high-grade glioma. (PubMed, J Neurooncol)
    Despite poor overall outcomes, incremental progress across targeted, immune, and delivery-based approaches supports a patient centered strategy emphasizing clinical-trial enrollment, molecular profiling and symptom focused care.
    Review • Journal • IO biomarker
    |
    BRAF (B-raf proto-oncogene) • NTRK (Neurotrophic receptor tyrosine kinase)
    |
    BRAF V600E • BRAF V600 • IDH mutation + BRAF V600E
    |
    Avastin (bevacizumab) • temozolomide • lomustine
    3ms
    IPAX BrIGHT: Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma (clinicaltrials.gov)
    P3, N=50, Recruiting, Telix Pharmaceuticals (Innovations) Pty Limited | Not yet recruiting --> Recruiting
    Enrollment open
    |
    lomustine
    3ms
    SONOBIRD: Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM (clinicaltrials.gov)
    P3, N=560, Active, not recruiting, CarThera | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    BRAF (B-raf proto-oncogene) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1)
    |
    BRAF mutation • IDH1 R132
    |
    carboplatin • temozolomide • lomustine
    4ms
    PersoMed-I: Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma (clinicaltrials.gov)
    P2, N=20, Terminated, European Organisation for Research and Treatment of Cancer - EORTC | Trial completion date: Dec 2025 --> Sep 2025 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2025 --> Jun 2025; Poor accrual
    Trial completion date • Trial termination • Trial primary completion date
    |
    TP53 (Tumor protein P53) • BRCA2 (Breast cancer 2, early onset) • MYCN (MYCN Proto-Oncogene BHLH Transcription Factor)
    |
    TP53 wild-type
    |
    cisplatin • vincristine • lomustine • Odomzo (sonidegib)
    4ms
    Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma (clinicaltrials.gov)
    P1, N=20, Recruiting, University of California, Davis | Not yet recruiting --> Recruiting
    Enrollment open
    |
    lomustine
    5ms
    Selection of tumor invasion-related genes to build a prognostic model and predict immune response and potential drugs for esophageal cancer patients based on WGCNA. (PubMed, Discov Oncol)
    The 10-gene prognostic model can independently predict patients' prognosis. The great correlation between ZC3H12B and multiple feature genes and immune cells may be tightly linked to EC progression.
    Journal
    |
    MAD1L1 (Mitotic Arrest Deficient 1 Like 1) • TWIST1 (Twist Family BHLH Transcription Factor 1) • TRIM28 (Tripartite Motif Containing 28)
    |
    lomustine • dexrazoxane
    5ms
    A Phase III Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma ( IPAX-3 ) - Part 1 (ACTRN12625000934448)
    P3, N=18, Not yet recruiting, Telix Pharmaceuticals
    New P3 trial
    |
    IDH wild-type
    |
    lomustine
    5ms
    Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma (clinicaltrials.gov)
    P1, N=20, Not yet recruiting, University of California, Davis
    New P1 trial
    |
    lomustine