Lymphoma

P3, N=156, Not yet recruiting, Ruijin Hospital

P1, N=24, Suspended, University of Utah | Recruiting --> Suspended

P1, N=30, Recruiting, The First Affiliated Hospital of Soochow University

P=N/A, N=30, Completed, Ohio State University Comprehensive Cancer Center | Active, not recruiting --> Completed

P1, N=18, Not yet recruiting, M.D. Anderson Cancer Center

Surgical margins were negative, and one-year follow-up showed that the patient remained disease-free. This case highlights the importance of immunohistochemistry and molecular testing for accurate diagnosis and appropriate management.

Synergistic effects with bortezomib (BTZ) were analyzed...SNG exerts potent anticancer effects in CTCL by inducing ROS-dependent mitochondrial apoptosis and inhibiting the PI3K/AKT/GSK3 signaling pathway. Its synergy with BTZ and computational validation of AKT/Bcl-2 targeting underscore its potential as a novel therapeutic candidate for CTCL, warranting further preclinical investigation.

Integration of artificial intelligence and point-of-care manufacturing may further streamline production and patient selection. Continued innovation will determine the long-term impact of CAR T-cell therapy as a scalable pillar of precision hematologic oncology.

Primary leiomyoma of the anterior mediastinum is extremely rare. Because primary mediastinal leiomyomas have nonspecific imaging features, distinguishing them from other anterior mediastinal tumors is challenging; thus, surgical resection is required for both diagnosis and treatment. Compared with the conventional look-up method, the confronting upside-down VATS technique utilizes higher intercostal access to provide a comprehensive thoracic view while minimizing diaphragmatic interference. The 180-degree rotated assistant monitor allows both surgeon and assistant to share a thoracotomy-like visual field, enhancing intraoperative coordination. In this case, it facilitated a stable operative field and phrenic nerve preservation despite the tumor's proximity without diaphragmatic interference. The confronting upside-down VATS technique may be particularly advantageous for anterior mediastinal tumors located along the phrenic nerve and in close proximity to the diaphragm.

RES also suppressed IL-6, IL-8, TNF-α, and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) expression, and enhanced anti-apoptotic genes B-cell lymphoma-extra-large and B-cell lymphoma 2 expression (P < 0.05). In conclusion, RES supplementation (400 mg/kg) effectively improved laying performance, egg quality, and oxidative and inflammatory responses in laying hens, suggesting its potential as a nutritional strategy to support laying performance during the late production stages.

CP and CPG patients have an increased lymphoma risk, linked to specific biomarkers, highlighting the importance of increased clinical vigilance in their management.

Aberrant B cell receptor signaling occurs in several B cell neoplasms including follicular lymphoma (treated with zanubrutinib, a BTK inhibitor), mantle cell lymphoma (acalabrutinib, pirtobrutinib, zanubrutinib), marginal zone lymphoma (zanubrutinib), chronic lymphocytic leukemia and small lymphocytic lymphoma (ibrutinib, acalabrutinib, zanubrutinib, pirtobrutinib), and Waldenström macroglobulinemia (ibrutinib, zanubrutinib)...Pirtobrutinib fails to form a covalent bond and is a reversible BTK inhibitor. The FDA-approvals of rilzabrutinib and remibrutinib (2025) represent the first nononcologic authorizations for BTK antagonists.