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    DRUG:

    megestrol

    i
    Other names: BDH 1298
    Company:
    Generic mfg.
    Drug class:
    Progesterone receptor agonist
    Related drugs:
    21d
    Megestrol Acetate for First-Line Treatment of Malnourished Non-Small Cell Lung Cancer (clinicaltrials.gov)
    P3, N=116, Not yet recruiting, Hunan Province Tumor Hospital
    New P3 trial
    |
    EGFR (Epidermal growth factor receptor)
    |
    megestrol
    25d
    FEMUS: Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification (clinicaltrials.gov)
    P2/3, N=260, Recruiting, Fudan University | Not yet recruiting --> Recruiting
    Enrollment open • Tumor mutational burden
    |
    PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • MSI (Microsatellite instability) • POLE (DNA Polymerase Epsilon)
    |
    ER positive • MSI-H/dMMR
    |
    Tyvyt (sintilimab) • letrozole • triptorelin • megestrol
    27d
    Long-term control for > 9 years with megestrol acetate-letrozole: metastatic endometrioid carcinoma case report. (PubMed, Front Oncol)
    At last follow-up (OS: 108 months), she maintained SD with minimal toxicity. This is the first case demonstrating that full-dose megestrol acetate plus letrozole may induce durable antitumor activity in HR-high expression metastatic EC, warranting prospective validation.
    Journal
    |
    ER (Estrogen receptor)
    |
    HR positive
    |
    letrozole • megestrol
    28d
    SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer (clinicaltrials.gov)
    P=N/A, N=82, Not yet recruiting, Hospital Universitari de Bellvitge
    New trial
    |
    TP53 wild-type
    |
    megestrol
    2ms
    Nano-Megestrol Acetate for Cancer Cachexia in Advanced Pancreatic Cancer (clinicaltrials.gov)
    P=N/A, N=56, Recruiting, Shandong Cancer Hospital and Institute
    New trial
    |
    5-fluorouracil • oxaliplatin • irinotecan • megestrol
    2ms
    Metformin combined with progesterone improves efficacy and reduces adverse reactions in early endometrial cancer. (PubMed, Am J Transl Res)
    Metformin combined with progesterone exerts excellent clinical efficacy in the treatment of early EC. It can significantly reduce serum tumor marker levels and BMI, and decrease the occurrence of adverse reactions.
    Journal
    |
    MMP9 (Matrix metallopeptidase 9) • CTGF (Connective tissue growth factor)
    |
    metformin • megestrol
    2ms
    Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients (clinicaltrials.gov)
    P3, N=360, Recruiting, Alliance for Clinical Trials in Oncology | Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Apr 2026 --> Apr 2027
    Trial completion date • Trial primary completion date
    |
    megestrol • olanzapine
    2ms
    A prospective, randomized, parallel controlled clinical trial of megestrol acetate oral suspension in patients with locally advanced nasopharyngeal carcinoma (ChiCTR2500114759)
    P=N/A, N=68, Not yet recruiting, Fujian Cancer Hospital; Fujian Cancer Hospital
    New trial
    |
    megestrol • TheraCIM (nimotuzumab)
    2ms
    A Prospective Real-World Observational Study of Nanocrystalline Megestrol Acetate in Patients with Cancer Cachexia (ChiCTR2500112934)
    P=N/A, N=495, Not yet recruiting, Henan Cancer Hospital; Henan Cancer Hospital
    New trial
    |
    megestrol
    2ms
    To evaluate the efficacy and safety of NEPA combined with Megestrol Acetate versus NEPA combined with Dexamethasone in preventing nausea and vomiting caused by T-Dxd in breast cancer patients (ChiCTR2600116296)
    P4, N=120, Not yet recruiting, Tianjin Cancer Hospital Airport Hospita; Tianjin Cancer Hospital Airport Hospita
    New P4 trial
    |
    Enhertu (fam-trastuzumab deruxtecan-nxki) • dexamethasone • megestrol
    2ms
    A Multicenter, Randomized, Controlled Phase II Clinical Trial of Nanocrystalline Megestrol Acetate versus Placebo for Anorexia in Patients with Unresectable Hepatocellular Carcinoma Receiving TACE Combined with Targeted and Immunotherapy (ChiCTR2600117241)
    P2, N=88, Not yet recruiting, Southern Medical University Southern Hospital; Southern Medical University Southern Hospital
    New P2 trial
    |
    megestrol
    3ms
    Nanocrystalline Megestrol Acetate for Cachectic Stage Locally Advanced Hepatocellular Carcinoma (clinicaltrials.gov)
    P3, N=68, Not yet recruiting, Changchun GeneScience Pharmaceutical Co., Ltd.
    New P3 trial
    |
    megestrol