Meningioma

This study provides genetic and functional evidence linking breast cancer to meningioma risk through DNA repair and hormonal pathways, supporting early risk assessment and targeted therapies to improve patient outcomes.

Medical therapy is typically ineffective or provides only transient relief,2 and stereotactic radiosurgery is often less effective than direct surgical decompression.3 While the retrosigmoid corridor is conventional, the anterior petrosal (Kawase) approach offers unique advantages for tumors involving the petrous apex and Meckel's cave.4-5 Approximately one-third of these tumors cause a concurrent neurovascular conflict.6 CASE DESCRIPTION: A 70-year-old woman, history of breast cancer, presented with Carbamazepine refractory sTN and suicidal ideation secondary to a petrous apex tumor with concurrent SCA compression...The anterior petrosal approach provides short, direct access to pre- and suprameatal pathology while avoiding manipulation of the lower cranial nerves. ESSENTIAL STEPS: frontotemporal craniotomy, MMA coagulation and division, posterior-to-anterior dural peeling to identify GSPN, identifying medial petrous ridge, petrous apex drilling guided by studying the preoperative CT scan, dural opening and dividing the tentorium (avoiding trochlear nerve), tumor resection from the trigeminal branches and AICA, SCA dissection from the trigeminal root entry zone, and Teflon interposition to address the dual-mechanism compression.

Importantly, co-targeting these pathways was able to overcome resistance to TEADi and was superior to MEK/mTOR/FAK inhibition alone. These studies provide a compelling proof-of-concept that TEADi represents a novel therapeutic vulnerability in meningioma and reveal adaptive signaling responses that can be therapeutically exploited.

The tumor was negative for a CDKN2A/B homozygous deletion and a TERT promoter mutation. Post-surgery, the patient showed immediate improvement in symptoms and was asymptomatic at the time of discharge and follow-up.

P=N/A, N=382, Recruiting, Medical University of Warsaw | Not yet recruiting --> Recruiting

The difference in intra-tumoral estrogen concentration is proposed as a potential cause for lower ER in ICM. Replacement of Dex and more sensitive ER assays are needed to determine the role of hormones in the causation and treatment of ER+ ICM.

P=N/A, N=0, Available, ITM Solucin GmbH

Germ cell tumorscannot be excluded in young male patients, even when lesions arise on the convexity and exhibit imaging features typical of meningiomas. Accordingly, germ cell tumors should be included in the differential diagnosis, and tumor marker evaluation and nuclear medicine studies should be proactively performed.

For astrocytoma, risk factors included Eotaxin, Macrophage colony-stimulating factor 1, and Interleukin-8; protective factors were T-cell surface glycoprotein CD5 and Tumor necrosis factor ligand superfamily member 12. This Mendelian randomization study identified specific inflammatory cytokines associated with these tumors, providing direction for future mechanistic research.

Surgical interventions addressed various complications, including meningiomas and renal hamartomas. The presented case offers valuable insights into the long-term natural history of AKT2-related hypoinsulinemic hypoglycemia and overgrowth syndrome, suggesting the importance of regular oncological surveillance due to its predisposition to tumorigenesis, thereby providing clinical considerations for future cases based on long-term follow-up experience.

After the operation, the patient was treated with vincristine-doxorubicin-cyclophosphamide and ifosfamide-etoposide chemotherapy, which resulted in a partial radiological response. This case illustrates the diagnostic difficulties associated with intracranial ES due to its radiological similarity to meningioma and stresses the importance of immunohistochemical and genetic analysis for a conclusive diagnosis. Early multimodal management is vital for improving survival in such rare cases.

No association was observed for in/near-field SNs or those without RT. Findings emphasize HRR variant-conferred susceptibility to RT-SNs and dose-dependent DNA damage repair.