Pharmacogenomic analysis identified nine compounds (Shikonin, Bicalutamide, Bryostatin-1, Epothilone-B, JNK-9L, LFM-A13, QS11, VX-680, and Z-LLNle-CHO) exhibiting differential sensitivity between the dichotomous risk strata. This study yields findings that hold significant clinical implications for refining prognostic stratification and deciphering the immune landscape in ESCC. Moreover, they offer novel perspectives that may pave the way for more precise prognostic assessment and the formulation of targeted therapeutic interventions.

P2, N=108, Not yet recruiting, Georgetown University

P1/2, N=75, Completed, University of Southern California | Unknown status --> Completed

Although less potent than the nanomolar-range reference drug Epothilone B (IC50 < 0.1 μM), rugulosin A showed submicromolar-to-low micromolar efficacy with notable selectivity toward cancer cells, which is considered significant for an unoptimized natural product scaffold. Its antiproliferative activity against K562 cells (GI50 = 3.69 μM), benchmarked against Imatinib (GI50 = 0.373 μM), also falls within the active range of natural product leads...Molecular docking revealed strong binding energies (-10.1, -9.8, and -11.0 kcal/mol), along with a stable molecular dynamics simulations data. These findings highlight rugulosin A (3) as a promising anticancer lead that modulates major apoptosis signaling pathways.

P1, N=34, Terminated, Conjupro Biotherapeutics, Inc. | N=126 --> 34 | Active, not recruiting --> Terminated; Business Decision

P3, N=0, Withdrawn, Relmada Therapeutics, Inc. | N=302 --> 0 | Not yet recruiting --> Withdrawn

P3, N=0, Withdrawn, Relmada Therapeutics, Inc. | N=85 --> 0 | Not yet recruiting --> Withdrawn

Given unresectability, the patient received toripalimab (240 mg) combined with docetaxel and cisplatin every 3 weeks. To our knowledge, this is the first reported case of toripalimab-based chemoimmunotherapy demonstrating an early partial response and short-term disease control in unresectable maxillary sinus NUT carcinoma. It supports the potential role of PD-1 blockade integrated with platinum-taxane chemotherapy as a component of multimodal management for sinonasal NUT carcinomas.

His treatment was started with docetaxel, receiving five cycles with good tolerance, after which he received hormonal treatment. After the infusion of 11 mL, the patient presented pharyngeal obstruction with dyspnoea, facial erythema, genital pruritus, and cervical pain that required treatment with intramuscular epinephrine. The results of the allergy study were not concordant with clinical presentation and confirmed the poor predictive value of taxane skin tests.

P3, N=393, Not yet recruiting, Relmada Therapeutics, Inc.

P1, N=16, Completed, RS Arastirma Egitim Danismanlik Ilac Sanayi Ticaret A.S. | Recruiting --> Completed | Trial completion date: Dec 2025 --> Mar 2026 | Trial primary completion date: Oct 2025 --> Mar 2026

NFE2L2 rs35652124C > T was identified as an independent predictive genetic factor for Grade 4 neutropenia in esophageal cancer patients treated with DCF chemotherapy.