nitroglycerin

The wound site was left open to promote healing; however, this was complicated by concomitant RDEB resulting in persisting well-demarcated ulceration unresponsive to topical Oleogel-S10, mupirocin 2% and Trimovate®. Botulinum toxin injections, topical glyceryl trinitrate and diltiazem are now being considered as the next step for this patient, with the aim of encouraging skin healing by relaxing the anal sphincter muscle...Additionally, this case presents the importance of tailored examinations under anaesthesia to facilitate perianal diagnoses in patients with EB, where skin fragility and pain limit the feasibility of routine examination methods. This case joins the existing literature that reports the challenges of wound healing in EB postoperatively, but importantly suggests that future management of other, nonsurgical perianal wounds in EB could also utilize similar techniques involving therapeutic anal sphincter muscle relaxation.

P4, N=440, Recruiting, National Cheng-Kung University Hospital | Not yet recruiting --> Recruiting

Our results demonstrated that Znhit1 ameliorated hyperalgesia and inhibited inflammatory response by suppressing the activation of NLRP3 inflammasome.

We also evaluated the effect of betamethasone on CGRP mRNA stability and release from the mouse TG, as well as on mouse spontaneous or nitroglycerin-induced cephalic allodynia.ResultsWe report that dexamethasone triggered transcriptional activation of the rat and human CGRP gene, also increasing transcript levels of RAMP1 but not of CLR in cultured cells. Of note, although a 13-fold increase of the CGRP releasable pool occurred in the TG of betamethasone-treated mice, the animals were not sensitized to cephalic allodynia.ConclusionsIn keeping with the emerging immunosuppressing effects of CGRP, corticosteroids increase its expression in rat and human cell lines, as well as in rodent TG. Evidence that a substantial increase of releasable CGRP in the TG does not reduce orofacial pain thresholds suggests that basal release of endogenous CGRP differs from its exogenous administration in terms of trigeminal afferent sensitization.

P=N/A, N=818, Not yet recruiting, Beijing Luhe Hospital, Capital Medical University; Beijing Luhe Hospital, Capital Medical University

On day 8, rat migraine models were established by subcutaneous injection of nitroglycerin...Warm needle acupuncture reduced ET-1 protein levels and promoted the expression of neurotransmitters, such as 5-hydroxytryptamine, in migraine rat model animals. In addition, needle warming acupuncture decreased IL-6, TNF-α, and CGRP levels in the brain stem of the migraine group, which may explain its mechanism of action in treating migraine.

P=N/A, N=20, Completed, Mansoura University

P=N/A, N=100, Not yet recruiting, Qilu Hospital of Shandong University

P1, N=15, Not yet recruiting, Johns Hopkins University | Initiation date: Aug 2025 --> Dec 2025 | Trial primary completion date: Jul 2026 --> Dec 2026

P1/2, N=60, Completed, Perth Children's Hospital(Child And Adolescent Health Service) | Recruiting --> Completed

In randomized stroke trials, the indirect NO donor glyceryl trinitrate lowered MAP but improved neither regional cerebral blood flow (rCBF) nor functional outcomes...During reperfusion, SIN-1 lowered MAP (P<0.001), decreased the no-reflow area (P=0.002), increased rCBF (P<0.001), increased spontaneous brain activity (P<0.001), and decreased extracellular potassium (P=0.008) and direct current potential (P=0.022) in both strains, consistent with less no-reflow and better recovery in SIN-1-treated animals. SIN-1 emerges as a promising antihypertensive in acute stroke as it paradoxically increases rCBF in ischemic tissue and reduces no-reflow.

P1, N=12, Active, not recruiting, Vanderbilt University | Trial completion date: Aug 2025 --> Aug 2026 | Trial primary completion date: Jul 2025 --> Jul 2026