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    DRUG:

    nitroglycerin

    Company:
    Generic mfg.
    Drug class:
    Guanylate cyclase stimulant
    Related drugs:
    7d
    Glyceryl Trinitrate Enhances Caffeine Cytotoxicity Under Metabolic Stress in Cancer Cells. (PubMed, Molecules)
    Nitroglycerin (glyceryl trinitrate, GTN), a nitric oxide donor, and 2-deoxy-D-glucose (2-DG), a glycolysis inhibitor, have individually demonstrated anticancer potential through modulation of cellular metabolism and redox balance. Nevertheless, these findings should be considered exploratory and hypothesis-generating because target expression, enzymatic activity, and pathway activation were not experimentally validated. Overall, the results suggest that GTN enhances caffeine-induced cytotoxicity under metabolically stressed conditions through combined metabolic and redox perturbation, although the magnitude of the response depends on cellular context and warrants further mechanistic investigation.
    Journal
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    ALDH2 (Aldehyde Dehydrogenase 2 Family Member) • ADORA2A (Adenosine A2a Receptor)
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    nitroglycerin
    11d
    Inhibiting astrocyte activation is effective in triptan-induced medication-overuse headache model and prolonged hyperalgesia. (PubMed, Headache)
    Our findings demonstrate that sustained astrocyte activation in TNC is a potential driver of prolonged hyperalgesia in triptan-induced MOH. Inhibiting astrocyte activity effectively reverses behavioral and molecular markers of MOH, highlighting astrocyte inhibition as a promising therapeutic strategy for MOH.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • SYP (Synaptophysin) • GFAP (Glial Fibrillary Acidic Protein)
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    nitroglycerin
    28d
    Malignant Extra-adrenal Paraganglioma of the Bladder: A Rare Clinical Entity. (PubMed, Cureus)
    Intraoperative hypertensive crisis (blood pressure (BP) 224/120 mmHg) was managed with nitroglycerin infusion...Radical surgery with meticulous perioperative hemodynamic control is the cornerstone in recurrent/metastatic disease. Lifelong follow-up with imaging and biochemical surveillance is mandatory.
    Journal
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    SYP (Synaptophysin)
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    nitroglycerin
    1m
    A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease (clinicaltrials.gov)
    P1, N=36, Not yet recruiting, Bayer | Trial completion date: Dec 2026 --> May 2027 | Trial primary completion date: Dec 2026 --> May 2027
    Trial completion date • Trial primary completion date
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    nitroglycerin
    1m
    Dexmedetomidine Versus Nitroglycerin on Surgical Field Quality and Drug Cost in Functional Endoscopic Sinus Surgeries (clinicaltrials.gov)
    P=N/A, N=66, Completed, Zagazig University
    New trial • HEOR
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    nitroglycerin
    1m
    A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease (clinicaltrials.gov)
    P1, N=36, Not yet recruiting, Bayer | Initiation date: Apr 2026 --> Sep 2026
    Trial initiation date
    |
    nitroglycerin
    2ms
    NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI (clinicaltrials.gov)
    P2, N=26, Not yet recruiting, Simon Fraser University | Trial completion date: Feb 2026 --> Feb 2028 | Trial primary completion date: Feb 2026 --> Feb 2028
    Trial completion date • Trial primary completion date
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    nitroglycerin
    2ms
    The Application of Goal-Directed Fluid Therapy Under the Guidance of SVV Combined with SVRI in Radical Surgery for Oral Cancer (ChiCTR2600118193)
    P=N/A, N=80, The Second Xiangya Hospital of Central South University; The Second Xiangya Hospital of Central South University
    New trial
    |
    nitroglycerin
    2ms
    A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease (clinicaltrials.gov)
    P1, N=36, Not yet recruiting, Bayer
    Trial initiation date
    |
    nitroglycerin
    2ms
    Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer. (clinicaltrials.gov)
    P=N/A, N=74, Recruiting, Instituto Nacional de Cancerologia de Mexico | Trial completion date: Feb 2026 --> Feb 2027 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
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    EGFR (Epidermal growth factor receptor)
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    EGFR mutation
    |
    nitroglycerin
    3ms
    SPY NITROPASTE: Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. (clinicaltrials.gov)
    P1, N=15, Not yet recruiting, Johns Hopkins University | Initiation date: Mar 2026 --> Nov 2026 | Trial primary completion date: Mar 2027 --> Sep 2027
    Trial initiation date • Trial primary completion date
    |
    nitroglycerin
    3ms
    Understanding relationships between skin microvascular and limb macrovascular structure and function assessed by optical coherence tomography and high-resolution ultrasound in response to physiological stimuli (flow-mediated dilation, local heating, carbon dioxide and glyceryl trinitrate) in healthy younger and older adults. (ACTRN12626000357358)
    P=N/A, N=80, Not yet recruiting, The University of Western Australia
    New trial
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    nitroglycerin