P2, N=102, Not yet recruiting, VA Office of Research and Development

Contemporary consensus places somatostatin‑receptor analogues (SSAs) such as 68Ga-DOTATATE and 64Cu-DOTATATE at the center of head‑and‑neck paraganglioma (HNPGL), SDHx‑mutated disease, sporadic or hereditary HNPGLs and metastatic PPGLs, while 18F‑FDOPA is increasingly favored for adrenal pheochromocytoma (PCC); and 18F‑FDG complements both by detecting aggressive biology. MIBG now is only considered for inoperable or metastatic PPGLs under consideration for 131I‑MIBG therapy.

P=N/A, N=40, Not yet recruiting, Beni-Suef University

This study aimed to elucidate the molecular mechanisms by which cocaine- and amphetamine-regulated transcript peptide (CART) regulates granulosa cell (GC) fate in Bos taurus follicles...CART's pro-apoptotic and anti-proliferative effects on GCs likely also involve other downstream targets in the altered proteome. These results demonstrate that CART reprograms the GC proteome and that downregulation of CLU is a pivotal event driving this shift toward a pro-apoptotic and anti-proliferative state, providing insights into the protein-centric mechanisms by which CART influences GC fate.

P1, N=20, Not yet recruiting, Wright State University

P3, N=300, Enrolling by invitation, Axsome Therapeutics, Inc.

P1, N=118, Recruiting, Vertex Pharmaceuticals Incorporated | Not yet recruiting --> Recruiting

P2, N=100, Recruiting, University of Michigan | Not yet recruiting --> Recruiting

A 79-year-old woman with suspected choroidal lesion underwent 18F-FDG PET/CT, which revealed a non-FDG-avid right thyroid lobe incidentaloma (4.8 cm in largest dimension) that was cold on 99mTc-thyroid scan, showed intense SSTR expression on 68Ga-DOTATATE PET/CT, and MIBG avidity on 131I-MIBG scan, thereby proving it to be of neural crest origin. Fine needle aspiration biopsy (FNAB) with immunohistochemistry was positive for GATA3 and synaptophysin and negative for CK7, PAX8, TTF1, and calcitonin, establishing the diagnosis of thyroid paraganglioma. Even though rare, the diagnosis of paraganglioma should be considered in SSTR and MIBG-avid thyroid nodules, as seen in this case.

P2, N=361, Completed, Duke University | Active, not recruiting --> Completed

Cyclophosphamide treatment induces profound suppression of ribosomal biogenesis, cytoplasmic translation, mitochondrial oxidative phosphorylation, and Wnt-associated regenerative programs in hair matrix cells, indicating a functional metabolic arrest preceding overt epithelial cell loss...Topical venlafaxine and its active metabolite desvenlafaxine preserved follicular architecture, suppressed apoptosis, and restored hair shaft elongation in both mouse CIA models and human hair follicle organ culture. At single-cell resolution, venlafaxine reversed epithelial translational shutdown, reactivated differentiation and Wnt signaling programs, and attenuated fibroinflammatory remodeling, thereby restoring paracrine niche signaling and matrix cell proliferation. Collectively, these findings redefine CIA as a disorder characterized by coordinated epithelial functional arrest and dermal inflammatory remodeling and identify venlafaxine as a potential pharmacological strategy to mitigate chemotherapy-associated hair loss.

Pharmacological inhibition of RBMS1 with nortriptyline (NTP) significantly attenuated renal fibrosis in unilateral ureteral obstruction (UUO) mice. These results reveal an RBMS1/ANXA8/PI3K/AKT regulatory axis in renal fibrosis, highlighting RBMS1 as a potential therapeutic target.