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    DRUG CLASS:

    PDE10 inhibitor

    Related drugs:
    15d
    MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis and are Clinically Relevant Across Central Nervous System Disorders. (PubMed, Cancer Res)
    The brain-penetrant drug ibudilast, which prevents the binding of MIF to CD74, decreased brain metastasis in experimental models in vivo and in patient-derived organotypic cultures ex vivo in a primary tumor-agnostic manner. These findings suggest that MIF/CD74-induced reprogramming of myeloid cells in brain disorders is a vulnerability that could be exploited therapeutically against brain metastases, and possibly other brain disorders.
    Journal
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    CD74 (CD74 Molecule) • IFNG (Interferon, gamma)
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    Eyevinal (ibudilast)
    1m
    Allevia2: Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome (clinicaltrials.gov)
    P2, N=164, Active, not recruiting, Noema Pharma AG | Trial primary completion date: Feb 2026 --> Jun 2026
    Trial primary completion date
    1m
    COMBAT-ALS: Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS (clinicaltrials.gov)
    P2/3, N=234, Active, not recruiting, MediciNova | Trial completion date: Dec 2026 --> Apr 2028 | Trial primary completion date: Dec 2025 --> Apr 2027
    Trial completion date • Trial primary completion date
    |
    Eyevinal (ibudilast)
    1m
    RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (clinicaltrials.gov)
    P2/3, N=460, Completed, University Health Network, Toronto | Suspended --> Completed
    Trial completion
    |
    Eyevinal (ibudilast)
    3ms
    Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users (clinicaltrials.gov)
    P2, N=176, Completed, VA Office of Research and Development | Recruiting --> Completed | N=120 --> 176 | Trial completion date: Jun 2026 --> Oct 2025
    Trial completion • Enrollment change • Trial completion date
    |
    Eyevinal (ibudilast)
    4ms
    Allevia2: Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome (clinicaltrials.gov)
    P2, N=164, Active, not recruiting, Noema Pharma AG | Recruiting --> Active, not recruiting
    Enrollment closed
    6ms
    Allevia2: Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome (clinicaltrials.gov)
    P2, N=180, Recruiting, Noema Pharma AG | Trial completion date: Dec 2026 --> Apr 2026 | Trial primary completion date: Dec 2026 --> Feb 2026
    Trial completion date • Trial primary completion date
    7ms
    COMBAT-ALS: Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS (clinicaltrials.gov)
    P2/3, N=234, Active, not recruiting, MediciNova | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Eyevinal (ibudilast)
    8ms
    RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (clinicaltrials.gov)
    P2/3, N=460, Suspended, University Health Network, Toronto | Trial completion date: Mar 2025 --> Dec 2025 | Active, not recruiting --> Suspended
    Trial completion date • Trial suspension
    |
    Eyevinal (ibudilast)
    8ms
    Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users (clinicaltrials.gov)
    P2, N=120, Recruiting, VA Office of Research and Development | Trial completion date: Dec 2025 --> Jun 2026 | Trial primary completion date: Jun 2025 --> Dec 2025
    Trial completion date • Trial primary completion date
    |
    Eyevinal (ibudilast)
    11ms
    MN-166-GBM-1201: Study to Evaluate Ibudilast and TMZ Combo Treatment in Newly Diagnosed and Recurrent Glioblastoma (clinicaltrials.gov)
    P1/2, N=64, Completed, MediciNova | Active, not recruiting --> Completed
    Trial completion
    |
    temozolomide • Eyevinal (ibudilast)
    11ms
    Ibudilast for Treating Alcohol Use Disorder (clinicaltrials.gov)
    P2, N=50, Active, not recruiting, University of Pennsylvania | Recruiting --> Active, not recruiting | Trial completion date: Dec 2028 --> Dec 2027 | Trial primary completion date: Dec 2027 --> Dec 2026
    Enrollment closed • Trial completion date • Trial primary completion date
    |
    Eyevinal (ibudilast)