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    GENE:

    PDGFRB (Platelet Derived Growth Factor Receptor Beta)

    i
    Other names: PDGFRB, Platelet Derived Growth Factor Receptor Beta, Platelet-Derived Growth Factor Receptor, Beta Polypeptide, Beta-Type Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Receptor Beta, Platelet-Derived Growth Factor Receptor 1, CD140 Antigen-Like Family Member B, PDGF-R-Beta, PDGFR-Beta, PDGFR-1, PDGFR1,Beta Platelet-Derived Growth Factor Receptor, Activated Tyrosine Kinase PDGFRB, CD140b Antigen, NDEL1-PDGFRB , CD140B, IBGC4, JTK12, PENTT, IMF1 , KOGS
    7d
    Clinical analysis of 7 cases of childhood acute lymphoblastic leukemia with PDGFRB rearrangement (PubMed, Zhongguo Dang Dai Er Ke Za Zhi)
    PDGFRB-rearranged ALL in children is uncommon, is most often detected in B-ALL, and presents at a relatively older age. Fusion partners are diverse and frequently co-occur with additional gene mutations. Despite high initial remission, MRD negativity and molecular clearance rates remain suboptimal, and allogeneic hematopoietic stem cell transplantation may improve prognosis.
    Retrospective data • Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RUNX1 (RUNX Family Transcription Factor 1) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • ETV6 (ETS Variant Transcription Factor 6) • IKZF1 (IKAROS Family Zinc Finger 1) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • PAX5 (Paired Box 5) • EBF1 (EBF Transcription Factor 1) • CCDC88C (Coiled-Coil Domain Containing 88C) • SSBP2 (Single Stranded DNA Binding Protein 2) • TAL1 (TAL BHLH Transcription Factor 1)
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    RET rearrangement
    7d
    Bioinformatics-Based Identification and Clinical Validation of CHST1 as a Potential Prognostic Gene Associated With EMT in Gastric Cancer. (PubMed, Front Biosci (Landmark Ed))
    CHST1 is highly expressed in GC and may influence GC progression by regulating the MAPK/ERK signaling pathway.
    Journal
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    PDGFRB (Platelet Derived Growth Factor Receptor Beta) • GPR176 (G Protein-Coupled Receptor 176) • P4HA3 (Prolyl 4-Hydroxylase Subunit Alpha 3)
    8d
    A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) (clinicaltrials.gov)
    P2, N=222, Recruiting, National Cancer Institute (NCI) | Phase classification: P3 --> P2
    Phase classification
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    ABL1 (ABL proto-oncogene 1) • CD19 (CD19 Molecule) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • CSF1R (Colony stimulating factor 1 receptor)
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    TruSight RNA Pan-Cancer Panel
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    dasatinib • imatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • Blincyto (blinatumomab) • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • thioguanine • Starasid (cytarabine ocfosfate)
    10d
    Manganese-tannic acid immunomodulators potentiate PDGFRβ CAR-T cell function for additive therapy against liver fibrosis. (PubMed, J Control Release)
    Furthermore, we discover a novel mechanism by which MT nanoparticles enhance the proliferation, and thus the cytotoxicity of PDGFRβ CAR-T cells by upregulating the activity of the RAS signaling pathway. Overall, our well-designed MT nanoparticle-modified PDGFRβ CAR-T cell immunotherapy strategy demonstrates excellent anti-fibrotic effects, providing a promising therapeutic regimen for hepatic fibrosis.
    Journal • IO biomarker
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    PDGFRB (Platelet Derived Growth Factor Receptor Beta)
    11d
    RelA Signaling in Scgb1a1+ Progenitors Mediates Lower Airway Epithelial Atypia in RSV-Induced Post-Viral Lung Disease. (PubMed, Int J Mol Sci)
    Moreover, ANGPTL4 is biologically active in the BALF of RSV-PVLD mice, inhibiting lipoprotein lipase activity. We conclude that RSV-PVLD is mediated, at least in part, by RelA signaling in Scgb1a1-derived epithelial progenitors, dysregulating ANGPTL4 signaling in an epithelial-mesenchymal niche, resulting in persistence of atypical alveolar epithelial cells with dysregulated of clock gene expression.
    Journal
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    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • TP63 (Tumor protein 63) • CLOCK (Clock Circadian Regulator) • LPL (Lipoprotein Lipase) • ANGPTL4 (Angiopoietin Like 4) • AQP3 (Aquaporin 3) • NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1)
    11d
    Myeloproliferative Neoplasm With Eosinophilia Exhibiting a Rare GOLGA4-PDGFRB Rearrangement in an Infant: Navigating a Rare Malignancy Amidst Limited Pediatric Guidelines. (PubMed, J Pediatr Hematol Oncol)
    A literature review of all children with PDGFRB rearrangement was collated in our analysis. The challenges of diagnosis, treatment, and follow-up posed by such a rare genetic disorder with no pediatric guidelines are being discussed.
    Journal
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    PDGFRB (Platelet Derived Growth Factor Receptor Beta) • GOLGA4 (Golgin A4)
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    imatinib
    13d
    Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and TKI Therapy Monitoring. (PubMed, Research (Wash D C))
    Critically, our data confirm that dynamic PDGFRβ expression changes induced by specific TKI therapies exhibit a proportional relationship with corresponding fluorescence intensity variations. This finding further supports an association between PDGFRβ expression dynamics and TKI resistance mechanisms, facilitating precise PDGFRβ monitoring and individualized therapeutic guidance.
    Journal
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    PDGFRB (Platelet Derived Growth Factor Receptor Beta)
    14d
    Myeloid Neoplasms With a t(5;12)(q31;p13) and an Associated ETV6::ACSL6 Gene Fusion Are Diagnostically Challenging and Have a Poor Prognosis. (PubMed, Genes Chromosomes Cancer)
    The median overall survival of 5 patients with available follow-up was 11 months. We conclude that the reciprocal translocation t(5;12)(q32;p13) requires a careful and step-wise diagnostic work-up to differentiate between an underlying ETV6::PDGFRB fusion gene with associated excellent prognosis on imatinib and an ETV6::ACSL6 fusion gene, for which the prognosis is poor and alloHCT appears to be a promising therapeutic option.
    Journal
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    TP53 (Tumor protein P53) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • ETV6 (ETS Variant Transcription Factor 6)
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    TP53 deletion
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    imatinib
    22d
    Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ. (PubMed, EJNMMI Radiopharm Chem)
    DOTA-ATH022 is a novel dimerized version of ATH001, with significantly improved affinity towards PDGFRβ. Retention of radiolabeled DOTA-ATH022 in PDGFRβ-avid tissues and tumors was increased, however uptake in solid tumor tissue was not improved.
    Journal
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    PDGFRB (Platelet Derived Growth Factor Receptor Beta)
    22d
    Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome (clinicaltrials.gov)
    P2, N=70, Active, not recruiting, National Institute of Allergy and Infectious Diseases (NIAID) | Trial completion date: Mar 2026 --> Mar 2027
    Trial completion date
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    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • FIP1L1 (Factor Interacting With PAPOLA And CPSF1)
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    imatinib • Jakafi (ruxolitinib)
    23d
    HEM-iSMART - Sub B: Medical-scientific study of dasatinib and venetoclax for children with relapsed or refractory leukemia or lymphoma with a mutation in the MAPK/SRC signaling pathway - HEM-iSMART Sub-protocol B (2022-501866-22-00)
    P1/2, N=20, Recruiting, Princess Maxima Center For Pediatric Oncology
    New P1/2 trial
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    ABL1 (ABL proto-oncogene 1) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • ETV6 (ETS Variant Transcription Factor 6) • NUP214 (Nucleoporin 214) • AGGF1 (Angiogenic Factor With G-Patch And FHA Domains 1) • SATB1 (SATB Homeobox 1)
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    ABL1 fusion
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    Venclexta (venetoclax) • dasatinib
    25d
    Isolation and Characterization of Marrow-Isolated Adult Multilineage Inducible (MIAMI) Cell-Derived Extracellular Vesicles Demonstrate Multifunctional Therapeutic Potential in Tissue Regeneration and Anti-Inflammatory Immunomodulation. (PubMed, Cells)
    Meanwhile, MSC-EVs induced heterogeneous responses. These findings establish MIA-EVs as a conditioning-resistant, systems-regulated, cell-free platform with regenerative, immunomodulatory, and cytoprotective potential under hostile microenvironments.
    Journal
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    PDGFRB (Platelet Derived Growth Factor Receptor Beta) • VEGFD (Vascular Endothelial Growth Factor D) • CDX2 (Caudal Type Homeobox 2) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IGFBP1 (Insulin Like Growth Factor Binding Protein 1)