^
    5d
    A051902: Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma (clinicaltrials.gov)
    P2, N=170, Suspended, Alliance for Clinical Trials in Oncology | Trial completion date: Jun 2026 --> May 2027 | Trial primary completion date: Jun 2026 --> May 2027
    Trial completion date • Trial primary completion date
    |
    PD-1 (Programmed cell death 1) • TNFRSF8 (TNF Receptor Superfamily Member 8) • BCL6 (B-cell CLL/lymphoma 6) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • ICOS (Inducible T Cell Costimulator) • MME (Membrane Metalloendopeptidase)
    |
    TNFRSF8 expression
    |
    doxorubicin hydrochloride • cyclophosphamide • etoposide IV • Copiktra (duvelisib) • vincristine • prednisone • Onureg (azacitidine oral)
    6d
    PTCL13: Ro Plus CHOEP as First Line Treatment Before HSCT in Young Patients With Nodal Peripheral T-cell Lymphomas (clinicaltrials.gov)
    P1/2, N=89, Completed, Fondazione Italiana Linfomi - ETS | Active, not recruiting --> Completed
    Trial completion
    |
    doxorubicin hydrochloride • cyclophosphamide • etoposide IV • prednisone • Istodax (romidepsin)
    6d
    2223-001: A First-in-Human Study of KK2223 in Participants with T-cell Non-Hodgkin Lymphoma (2025-522523-96-00)
    P1, N=17, Not yet recruiting, Kyowa Kirin Inc.
    New P1 trial • First-in-human
    7d
    Exploiting ALK inhibition in anaplastic large cell lymphoma: Biological rationale and therapeutic integration. (PubMed, Br J Haematol)
    Small-molecule ALK inhibitors, including crizotinib, have demonstrated high overall response rates (67%-88%) and complete remission rates (~60%-80%) in relapsed or refractory ALK-positive ALCL, often with rapid clinical responses...In addition, it explores emerging strategies for integrating ALK inhibitors into precision-based management of T-cell lymphomas, including combination approaches with chemotherapy, immunotherapy or antibody-drug conjugates. Collectively, these developments highlight a paradigm shift towards biology-driven, personalized therapy in ALK-positive ALCL.
    Review • Journal • IO biomarker
    |
    ALK (Anaplastic lymphoma kinase) • mTOR (Mechanistic target of rapamycin kinase) • STAT3 (Signal Transducer And Activator Of Transcription 3)
    |
    ALK positive • ALK fusion • ALK mutation • ALK G1202R
    |
    Xalkori (crizotinib)
    7d
    T-START-M1: Golidocitinib Versus Placebo as Maintenance Therapy for Peripheral T-Cell Lymphoma (clinicaltrials.gov)
    P3, N=136, Recruiting, Fudan University | Not yet recruiting --> Recruiting
    Enrollment open
    |
    golidocitinib (DZD4205)
    13d
    A Case of Angioimmunoblastic T-Cell Lymphoma Misdiagnosed as Eczema-Like Dermatitis in an Elderly Patient. (PubMed, Clin Cosmet Investig Dermatol)
    This case underscores the diagnostic complexity of AITL presenting with predominant allergic-like skin lesions and highlights the importance of considering underlying lymphoproliferative disorders in elderly patients with persistent, recurrent, or atypical dermatoses. Timely histopathological and immunophenotypic evaluation is essential for accurate diagnosis and appropriate management.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-1 (Programmed cell death 1) • BCL6 (B-cell CLL/lymphoma 6) • CD4 (CD4 Molecule) • CD5 (CD5 Molecule) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • MME (Membrane Metalloendopeptidase)
    13d
    Genotype-guided Targeted Agents Plus EZH2i for Primary Refractory PTCL (clinicaltrials.gov)
    P1/2, N=86, Not yet recruiting, Ruijin Hospital
    New P1/2 trial
    |
    azacitidine • decitabine • Epidaza (chidamide) • zeprumetostat (SHR-2554) • golidocitinib (DZD4205)
    13d
    CFT7455-1101: Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma (clinicaltrials.gov)
    P1, N=224, Active, not recruiting, C4 Therapeutics, Inc. | Trial completion date: Mar 2026 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Sep 2026
    Trial completion date • Trial primary completion date
    |
    dexamethasone • cemsidomide (CFT7455)
    14d
    Tracing the Analytical Footprint of Belinostat: Exploring Pharmacology and Synthetic Framework. (PubMed, Biomed Chromatogr)
    Belinostat and its potential metabolites have often been qualitatively and quantitatively estimated and tracked using several analytical methods including UPLC-MS/MS, HPLC-UV, FTIR, TLC, NMR, and ESI-MS. In terms of therapeutic use of belinostat, this review demonstrates how important it is to understand the metabolism and degradation pathways of belinostat, as well as possible drug-drug interactions.
    Review • Journal
    |
    UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
    |
    Beleodaq (belinostat)
    14d
    A challenging case of facial oedemas revealing a systemic peripheral T-cell lymphoma, not otherwise specified. (PubMed, Eur J Dermatol)
    In our case, as extracutaneous disease was present from the beginning, the diagnosis would be better classified as systemic (non-primary cutaneous) PTCL-NOS. This report emphasizes the importance of repeated biopsies and expert reviews for diagnosing and managing PTCL, which can have a highly variable and poor prognosis.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD5 (CD5 Molecule) • GZMB (Granzyme B) • CD7 (CD7 Molecule) • CD2 (CD2 Molecule) • PRF1 (Perforin 1)
    14d
    Exploratory Clinical Study of SHR-0302 and SHR-2554 in Patients With Relapsed/Refractory Peripheral T Cell Lymphoma (clinicaltrials.gov)
    P2, N=25, Recruiting, Fudan University | Trial primary completion date: Feb 2026 --> Feb 2027
    Trial primary completion date
    |
    zeprumetostat (SHR-2554) • AiSuDa (ivarmacitinib)