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    DRUG CLASS:

    Progesterone receptor agonist

    Related drugs:
    23h
    A Study in Japanese Healthy Men to Test How Well Different Doses of BI 3031185 Are Tolerated and a Study in Japanese Healthy Women to Test Whether BI 3031185 Influences the Amount of a Contraceptive in the Blood (clinicaltrials.gov)
    P1, N=36, Not yet recruiting, Boehringer Ingelheim
    New P1 trial
    |
    midazolam hydrochloride
    2d
    MP4 MPS: Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS) (clinicaltrials.gov)
    P1, N=20, Completed, McMaster University | Not yet recruiting --> Completed | Trial completion date: Dec 2025 --> May 2026 | Initiation date: Sep 2025 --> Jan 2026 | Trial primary completion date: Dec 2025 --> May 2026
    Trial completion • Trial completion date • Trial initiation date • Trial primary completion date
    2d
    Phase 2 Cachexia Clinical Trial to Evaluate the Efficacy and Safety of ASCA101 (clinicaltrials.gov)
    P2, N=135, Recruiting, MetaFines | Not yet recruiting --> Recruiting | Trial completion date: Jul 2027 --> Jun 2028 | Initiation date: Sep 2025 --> May 2026 | Trial primary completion date: Mar 2026 --> Apr 2028
    Enrollment open • Trial completion date • Trial initiation date • Trial primary completion date
    |
    megestrol
    3d
    Fetal Growth Restriction a Case Control Study (clinicaltrials.gov)
    P=N/A, N=58, Recruiting, National University of Malaysia | Not yet recruiting --> Recruiting
    Enrollment open
    |
    HMOX1 (Heme Oxygenase 1)
    7d
    SCD CURE: Effects of the Contraceptive Implant in Women With Sickle Cell Disease (clinicaltrials.gov)
    P4, N=22, Active, not recruiting, University of Pennsylvania | Recruiting --> Active, not recruiting | Trial completion date: Jun 2026 --> Mar 2027 | Trial primary completion date: Jun 2026 --> Mar 2027
    Enrollment closed • Trial completion date • Trial primary completion date
    7d
    Endometrial BCL6 Expression and Reproductive Outcomes in Infertile Women: A Systematic Review. (PubMed, Diagnostics (Basel))
    Background/Objectives: Endometrial B-cell lymphoma 6 (BCL6) overexpression has been proposed as a marker of progesterone resistance, occult endometriosis, and endometrial dysfunction in infertile women...Its apparent prognostic and clinical utility varies across patient populations and reproductive settings. Larger prospective comparative studies with harmonized biopsy protocols, standardized outcome reporting, and independent external validation are needed to clarify the role of BCL6 in reproductive medicine.
    Review • Journal
    |
    BCL6 (B-cell CLL/lymphoma 6)
    7d
    The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial (clinicaltrials.gov)
    P3, N=110, Recruiting, Main Line Health | Trial completion date: Aug 2026 --> Dec 2028 | Trial primary completion date: Feb 2026 --> Jun 2028
    Trial completion date • Trial primary completion date
    |
    Orgovyx (relugolix)
    7d
    Intrauterine Stent Placement Following Hysteroscopic Septum Resection (clinicaltrials.gov)
    P=N/A, N=320, Recruiting, Weill Medical College of Cornell University | Not yet recruiting --> Recruiting
    Enrollment open
    |
    medroxyprogesterone
    10d
    Prolonged Progesterone to Prevent Preterm Birth From IVF - ET (clinicaltrials.gov)
    P4, N=100, Recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Not yet recruiting --> Recruiting | Trial completion date: Feb 2025 --> Apr 2029 | Trial primary completion date: Feb 2025 --> Apr 2029
    Enrollment open • Trial completion date • Trial primary completion date
    15d
    Immediate vs Delayed Postpartum Implanon-NXT (clinicaltrials.gov)
    P=N/A, N=90, Not yet recruiting, Assiut University
    New trial • Adverse events
    16d
    Establishment and characterization of an immortalized bovine luteal cell line. (PubMed, Front Vet Sci)
    The bovine corpus luteum (CL) is critical for pregnancy establishment and maintenance via progesterone (P4) secretion...Furthermore, Co-culture with SV40T-IBLC significantly enhanced the viability of bovine endometrial epithelial cells (BEEC) by 34.2% after 72 h of co-incubation (p < 0.01), increased intracellular lipid droplet abundance of BEEC, and upregulated the mRNA expression of endometrial receptivity-related genes including EGF and LIF, with no significant alteration in BEEC apoptosis rate. In conclusion, this immortalized cell line retains core functional characteristics of PBLC, providing a stable, homogeneous in vitro model for bovine reproductive research.
    Preclinical • Journal
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    EGF (Epidermal growth factor) • SYP (Synaptophysin)
    16d
    Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy (clinicaltrials.gov)
    P2, N=44, Active, not recruiting, City of Hope Medical Center | Trial completion date: Mar 2026 --> Feb 2027
    Trial completion date • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2)
    |
    megestrol