RAD51D (RAD51 paralog D)

P1/2, N=210, Recruiting, Shanghai SciBrunch Therapeutics Co., Ltd. | Not yet recruiting --> Recruiting

P2, N=120, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Feb 2026 --> Dec 2029 | Trial primary completion date: Feb 2026 --> Dec 2029

BRCA2 is the most common gene with germline variations, while CDK12 is the most frequently mutated gene in somatic HRR variants. This study suggests that HRR gene testing in patients with high-risk HSPC would help identify those with more aggressive clinical features and guide prognostication and potential targeted therapeutic strategies.

An exploratory approach consisting of unmasking the results of the NGS analysis of 123 « research » genes involved in the carcinogenesis was applied to the 447 patients tested negative for the different genes of our diagnostic panel. This approach failed to identify other susceptibility genes to pancreatic adenocarcinoma.

P2, N=32, Recruiting, Rana McKay, MD | Trial primary completion date: Dec 2025 --> Mar 2026

P1/2, N=210, Not yet recruiting, Shanghai SciBrunch Therapeutics Co., Ltd.

P2, N=60, Active, not recruiting, Xiao X. Wei, MD | Trial completion date: Dec 2025 --> Jun 2026

Genetic counseling and testing for patients diagnosed with breast or OC can identify HBOC risk, reducing complications and mitigating lifetime cancer risk through timely assessment and awareness.

P2, N=334, Not yet recruiting, Fudan University

In this study, we evaluated the cytotoxic, genotoxic, and DNA repair response effects of particulate Cr(VI) in alligator lung cells after acute (24 h) and prolonged (120 h) exposures. These data indicate alligators have evolved protective measures against DNA damage induced by Cr at the cellular or molecular levels, which likely leads to protection against other chemical carcinogens that cause DNA double strand breaks. These findings inform chemical carcinogenesis in humans and support the use of alligators as sentinel species for monitoring the health impacts of Cr(VI) contamination in aquatic environments.

Together, we identify hotspots of deleterious RAD51D variants and uncover the mechanisms by which variants compromise its biochemical functions. Used a multiplexed assay of functional effect (MAVE) to assess the functionality via olaparib sensitivity of 6,888 RAD51D coding variants, which can be used for variant classification Provided cellular functional analysis for 70 clinically-identified breast and ovarian cancer RAD51D variants Identified key regions and enzymatic activities of RAD51D critical for its function in the BCDX2 and the X3CDX2 complexesDetermined mechanism of RAD51D-mediated regulation of BCDX2 ATPase activity.

This review provides a comprehensive overview of hereditary tumor syndromes predisposing to breast and gynecologic malignancies, with a focus on genetic basis, associated cancer risks, and implications for clinical management. By delineating these syndromes, it aims to assist clinicians in recognizing hereditary cancer predisposition and in guiding affected individuals within routine senologic and gynecologic practice.