^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    CANCER:

    Rectal Cancer

    Related cancers:
    14h
    GYNERECT: Evaluation of Gynecological and Sexual Sequelae (clinicaltrials.gov)
    P=N/A, N=15, Not yet recruiting, University Hospital, Rouen
    New trial
    14h
    Modified Title Project 4: Effect of Meal Timing During Cancer Treatment in Alaska Native Patients (clinicaltrials.gov)
    P=N/A, N=100, Recruiting, Fred Hutchinson Cancer Center | Not yet recruiting --> Recruiting
    Enrollment open
    |
    HER-2 (Human epidermal growth factor receptor 2)
    1d
    Cognitive-Behavioral Sleep and Nutritional Intervention Enhances Recovery and Survival in Rectal Cancer Patients Undergoing Abdominoperineal Resection: A Randomized Controlled Trial. (PubMed, Biopsychosoc Sci Med)
    Integrating CBSI with nutritional support significantly improved sleep, psychological well-being, inflammation, and survival in rectal cancer patients undergoing APR, supporting its inclusion in perioperative oncology care.
    Journal
    |
    IL6 (Interleukin 6)
    2d
    Digitally Delivered Cognitive Behavioral Therapy (CBT) and Inflammation-Guided Nutrition to Enhance Recovery and Survival After Abdominoperineal Resection (APR): A Prospective Non-Randomized Controlled Cohort Study. (PubMed, Ann Nutr Metab)
    Among patients undergoing APR managed within an ERAS pathway, the addition of digital CBT and inflammation-guided nutrition was associated with improved multidimensional recovery and favorable survival signals. Given the non-randomized design, these results should be regarded as hypothesis-generating and support further evaluation of ERAS-based integrative strategies in randomized multicenter trials.
    Journal
    |
    IL6 (Interleukin 6) • CRP (C-reactive protein)
    3d
    CAPOX and Bevacizumab With or Without Primary Tumor Radiotherapy and Iparomlimab and Tuvonralimab as First-line Treatment for RAS-Mutant/MSS Metastatic Rectal Cancer (clinicaltrials.gov)
    P2, N=106, Not yet recruiting, Peking University Cancer Hospital & Institute
    New P2 trial • IO biomarker
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    KRAS mutation • BRAF mutation • NRAS mutation • BRAF V600
    |
    Avastin (bevacizumab) • capecitabine • oxaliplatin • Qibeian (iparomlimab/tuvonralimab) • iparomlimab (QL1604)
    4d
    Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer (FIRM02 Study) (clinicaltrials.gov)
    P2, N=128, Not yet recruiting, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
    New P2 trial • pMMR
    |
    MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2)
    |
    5-fluorouracil • oxaliplatin • leucovorin calcium • Hetronifly (serplulimab)
    5d
    A Study of Tucatinib and Trastuzumab in People With Rectal Cancer (clinicaltrials.gov)
    P2, N=37, Recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase)
    |
    HER-2 positive • HER-2 overexpression • HER-2 amplification • RAS wild-type • HER-2 positive + HER-2 overexpression • HER-2 positive + RAS wild-type
    |
    Herceptin (trastuzumab) • Tukysa (tucatinib)
    6d
    A retrospective single-center clinical study on the impact of neoadjuvant therapy on intestinal fistula formation after colorectal cancer surgery. (ChiCTR2600117650)
    P=N/A, N=1000, Not yet recruiting, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University o
    New trial
    6d
    Central Mechanisms Underlying the Influence of Genetic Polymorphisms on Individual Differences in Postoperative Analgesia Following Hydrocodone Bitartrate Injection: An EEG and fMRI Analysis (ChiCTR2600117536)
    P=N/A, N=60, Not yet recruiting, Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical Co
    New trial
    6d
    To investigate the efficacy and safety of irinotecan liposome combined with fluorouracil and oxaliplatin as neoadjuvant therapy for locally advanced rectal cancer (ChiCTR2600117281)
    P=N/A, N=34, Not yet recruiting, Tianjin Medical University General Hospital; Tianjin Medical University General Hospital
    New trial
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation • RAS mutation
    |
    5-fluorouracil • leucovorin calcium
    6d
    Application and Exploration of Personalized ctDNA - MRD Detection Technology in Efficacy Prediction of Neoadjuvant Therapy for Rectal Cancer (ChiCTR2600116652)
    P=N/A, N=60, Not yet recruiting, Beijing Friendship Hospital, Capital Medical University; Beijing Friendship Hospital, Capital Medical University
    New trial
    6d
    Electroacupuncture to Prevent Urinary Retention after Laparoscopic Rectal Cancer Resection: A Prospective, Multicenter, Randomized Controlled Trial (ChiCTR2500115793)
    P=N/A, N=250, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University
    New trial