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    DRUG:

    Anyouping (finotonlimab)

    i
    Other names: SCT-I10A, SCT-I10, SCT I10A, SCTI10A
    Associations

    News

    Trials
    Company:
    Sinocelltech
    Drug class:
    PD1 inhibitor
    Related drugs:
    Associations

    News

    Trials
    2ms
    A prospective, multicenter, randomized, controlled, open-label trial to evaluate the efficacy and safety of Finotonlimab in locally advanced head and neck squamous cell carcinoma (ChiCTR2600117055)
    P4, N=292, Not yet recruiting, Fudan University Shanghai Cancer Center; Fudan University Shanghai Cancer Center
    New P4 trial
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    Anyouping (finotonlimab)
    2ms
    A Prospective, Single-Arm, Phase II Clinical Study of Finotonlimab Combined with Carboplatin and Nab-Paclitaxel in the Treatment of Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma (ChiCTR2500112241)
    P2, N=35, Not yet recruiting, SUN YAT-SEN MEMORIAL HOSPITAL; SUN YAT-SEN MEMORIAL HOSPITAL
    New P2 trial
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    carboplatin • albumin-bound paclitaxel • Anyouping (finotonlimab)
    4ms
    Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma (clinicaltrials.gov)
    P2, N=116, Recruiting, Eye & ENT Hospital of Fudan University | Not yet recruiting --> Recruiting
    Enrollment open
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    cisplatin • albumin-bound paclitaxel • Anyouping (finotonlimab)
    4ms
    Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma (clinicaltrials.gov)
    P2, N=116, Not yet recruiting, Eye & ENT Hospital of Fudan University
    New P2 trial
    |
    cisplatin • albumin-bound paclitaxel • Anyouping (finotonlimab)
    5ms
    Induction chemotherapy combined with Finotonlimab ± high and low-dose radiotherapy in Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma: a Multi-center, Open-label,Randomized Controlled Phase II Clinical Trial (ChiCTR2500109989)
    P2, N=84, Not yet recruiting, Jiangxi cancer hospital; Jiangxi cancer hospital
    New P2 trial
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    cisplatin • paclitaxel • Anyouping (finotonlimab)
    6ms
    Cost-effectiveness analysis of first-line treatments for recurrent or metastatic head and neck cancer in China: an economic evaluation based on network meta-analysis. (PubMed, Front Pharmacol)
    From the perspective of the Chinese population, finotonlimab-chemotherapy is the most cost-effective first-line treatment for R/M HNSCC, followed by cetuximab-chemotherapy. Pembrolizumab, whether as monotherapy or in combination, does not offer economic benefits.
    Retrospective data • Journal • HEOR • Cost-effectiveness
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    PD-L1 (Programmed death ligand 1)
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    Keytruda (pembrolizumab) • Erbitux (cetuximab) • Anyouping (finotonlimab)
    6ms
    An anti-PD-1 antibody (SCT-I10A) plus anti-EGFR antibody (SCT200) and chemotherapy for RAS/BRAF wild-type metastatic colorectal cancer: A phase Ib study. (PubMed, Cancer Lett)
    Immunotherapy has demonstrated limited efficacy against microsatellite-stable (MSS) metastatic colorectal cancer (mCRC). Oxaliplatin may induce greater immune activation, with GZMA and CXCL13 serving as potential prognostic biomarkers. Thus, combining immunotherapy, EGFR inhibitors, and XELOX represents an optimal therapeutic strategy for mCRC.
    P1 data • Journal • PD(L)-1 Biomarker • IO biomarker
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    BRAF (B-raf proto-oncogene) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • GZMA (Granzyme A)
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    BRAF wild-type
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    capecitabine • oxaliplatin • SCT200 • Anyouping (finotonlimab)
    8ms
    Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/ Metastatic HNSCC ( LONG'E ) (ChiCTR2500105767)
    P1, N=10, Not yet recruiting, Bejing Tongren Hospital, Capital Medical Uniersity; Bejing Tongren Hospital, Capital Medical Uniersity
    New P1 trial
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    PD-L1 (Programmed death ligand 1)
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    PD-L1 expression
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    Anyouping (finotonlimab) • Kangyueda (stapokibart)
    10ms
    LONG'E: Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCC (clinicaltrials.gov)
    P1, N=10, Not yet recruiting, Beijing Tongren Hospital
    New P1 trial
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    Anyouping (finotonlimab) • Kangyueda (stapokibart)
    10ms
    A Multicenter, Prospective Study of Perioperative Finotonlimab Combined With Bevacizumab in Resectable Hepatocellular Carcinoma Patients With High-Risk Factors for Recurrence (clinicaltrials.gov)
    P=N/A, N=130, Active, not recruiting, Tongji Hospital
    New trial
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    Avastin (bevacizumab) • Anyouping (finotonlimab)
    10ms
    Finotonlimab with taxane/platinum chemotherapy or cetuximab as first-line therapy for recurrent or metastatic head and neck squamous cell carcinoma: a real-world study (ChiCTR2500103475)
    P4, N=300, Not yet recruiting, Shanghai East Hospital; Shanghai East Hospital
    New P4 trial • Real-world evidence
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    Erbitux (cetuximab) • Anyouping (finotonlimab)
    2years
    SCT-I10A or Placebo Plus Docetaxel With Previously Treated Squamous Cell Non-small Cell Lung Cancer (clinicaltrials.gov)
    P3, N=188, Terminated, Sinocelltech Ltd. | N=360 --> 188 | Active, not recruiting --> Terminated | Trial primary completion date: Oct 2022 --> Feb 2023; Strategy adjustments, independent of the safety and efficacy of the trial medication
    Enrollment change • Trial termination • Trial primary completion date • Metastases
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    EGFR mutation
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    docetaxel • Anyouping (finotonlimab)