High AMBP expression associates with CCA tumorigenesis, immunosuppression, and poor prognosis, acting via WNT. Huaier polysaccharide reverses CCA malignancy by inhibiting AMBP, reducing invasiveness/metastasis and improving prognosis.

26 days ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1)

Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102) (clinicaltrials.gov)

P1, N=30, Recruiting, Ensysce Biosciences | N=50 --> 30 | Trial completion date: Mar 2026 --> Dec 2026 | Trial primary completion date: Jan 2026 --> Jul 2026

1 month ago

Enrollment change • Trial completion date • Trial primary completion date

Epinephrine-Added Irrigation Versus Intravenous Tranexamic Acid in Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Trial (clinicaltrials.gov)

P=N/A, N=80, Completed, Saglik Bilimleri Universitesi

1 month ago

New trial

The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients (clinicaltrials.gov)

P2, N=50, Recruiting, Stanford University | Trial completion date: Jan 2026 --> Jan 2027 | Trial primary completion date: Jan 2026 --> Jan 2027

1 month ago

Trial completion date • Trial primary completion date

2ms

Effects of Red and Infrared Photobiomodulation in Rhinoplasty at a Single Centre (clinicaltrials.gov)

P=N/A, N=60, Recruiting, University of Nove de Julho | Not yet recruiting --> Recruiting | Trial completion date: Jul 2030 --> Nov 2030 | Initiation date: Oct 2025 --> Jan 2026

2 months ago

Enrollment open • Trial completion date • Trial initiation date

2ms

Comparison of Anticoagulant Effects Between Nafamostat Mesylate and Sodium Citrate in Double Filtration Plasmapheresis (ChiCTR2600117445)

P=N/A, N=140, Not yet recruiting, The First Affiliated Hospital of Army Medical University PLA; The First Affiliated Hospital of Army Medical University PLA

2 months ago

New trial

nafamostat

2ms

A Randomized, Active-Controlled, Open-Label Clinical Study of Nafamostat Mesylate for Reducing Bleeding Risk in Maintenance Hemodialysis Patients at High Risk of Bleeding (ChiCTR2600116304)

P=N/A, N=338, Not yet recruiting, The Seventh Affiliated Hospital Sun Yat-sen University; The Seventh Affiliated Hospital of Sun Yat-sen University

2 months ago

New trial

nafamostat • enoxaparin sodium

2ms

HSP90α and KLK6 Coregulate Stress-Induced Prostate Cancer Cell Motility. (PubMed, Cells)

Screening for protease inhibitors that would rescue stress-induced decreases in MMP-2 activity identified a single serine protease inhibitor: aprotinin...In conclusion, we identify a novel stress-induced extracellular network that regulates MMP-2 activity and cell motility. We identified KLK6 as a stress-induced extracellular protease leading to decreased MMP-2 activity and cellular invasion, while eHSP90α is required for the rescue of MMP-2 activity once KLK6 is neutralized.

2 months ago

Journal

MMP2 (Matrix metallopeptidase 2) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • KLK6 (Kallikrein Related Peptidase 6)

2ms

Exploring Molecular Signature and Prognostic Biomarkers in Ovarian Cancer: Insights From Late-Stage, Recurrent, and Metastatic Tumors. (PubMed, Biotechnol Appl Biochem)

Ocriplasmin and pamidronate were identified as potential therapeutics. Our findings highlight the therapeutic relevance of these hub genes and identify them as potential drug targets and prognostic biomarkers in ovarian cancer.

2 months ago

Journal

CXCL8 (Chemokine (C-X-C motif) ligand 8) • IGF1 (Insulin-like growth factor 1) • FN1 (Fibronectin 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • COL3A1 (Collagen Type III Alpha 1 Chain) • MIR29A (MicroRNA 29a) • POSTN (Periostin)

pamidronate disodium