Together, these findings indicate that acute treatment with risperidone in male mice exerts pronounced molecular effects in medial and ventral forebrain regions with high oligodendrocyte and glial cell abundance. Moreover, enrichment analysis points to a molecular convergence between risperidone-induced transcription and genetic pathways implicated in schizophrenia.

P=N/A, N=42, Completed, Hasanuddin University

P4, N=120, Recruiting, Northwell Health | Phase classification: P --> P4

P2, N=128, Recruiting, University of Calgary | Not yet recruiting --> Recruiting

P=N/A, N=104, Not yet recruiting, Eastern Health

P1, N=85, Recruiting, Medical University of Vienna

P2, N=80, Completed, Hasanuddin University

P4, N=180, Recruiting, Northwell Health | Not yet recruiting --> Recruiting

P=N/A, N=80, Completed, Hasanuddin University

In addition, advanced molecular docking analysis demonstrated strong binding affinity of engeletin with the key regulatory proteins SMAD3 (-9.3 kcal/mol) and NF-κB p65 (-9.1 kcal/mol), providing strong evidence that ENG can directly interact with the central regulators of the TGF-β1/Smad and NF-κB signaling pathways. In conclusion, ENG significantly ameliorated RIS-induced hepatotoxicity, highlighting its potential as hepatoprotective adjuvant therapy.

P=N/A, N=50, Completed, Hasanuddin University

Within 6 months of initiation, risperidone use in drug-naive pediatric patients was associated with increased weight and abdominal adiposity, early prolactin elevation, HDL reduction, and clinical improvement. Waist circumference showed a strong dose-dependent association and should be routinely monitored along with metabolic and endocrine parameters.