Skin Cancer

P=N/A, N=30, Active, not recruiting, Alpha Tau Medical LTD. | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026

Lymphangiosarcoma has not been previously reported in non-human primates, to our knowledge. Our case highlights the importance of integrating histopathology, immunohistochemistry, and ultrastructural analysis to accurately diagnose rare vascular tumors, such as lymphangiosarcoma.

The systematic review partially confirmed the safety of JAK inhibitors in IMIDs. This study supports TYK2 inhibition as a targeted therapy for psoriasis and provides hypothesis-generating genetic evidence for additional target-disease and target-safety associations that warrant further validation.

The XP-C mutational profile was characterized by elevated single-nucleotide variants (SNVs) associated with mutational signatures SBS5, SBS8, and SBS32, as well as an enrichment of single-nucleotide cytosine deletions, with SNV profiles closely mirroring those found in XP-C leukemias. These findings indicate that a cancer-like mutation burden is already present in normal lymphocytes before malignant transformation, revealing distinct molecular subtypes within XP defined by spontaneous mutational load in normal blood cells.

However, the observed results should be interpreted with caution considering the limitations of the dataset. These findings provide valuable insight into the epidemiology of and safety considerations for patients with vitiligo in the United States, informing future clinical and therapeutic strategies.

Despite timely whole-brain radiotherapy and chemotherapy, his condition deteriorated rapidly, and he succumbed within weeks. This case highlights the rare presentation of small-cell lung carcinoma with cutaneous metastases, which is associated with poor prognosis.

This review systematically explores the molecular mechanisms of THBS1 signaling in the skin, highlighting its implications in wound healing, tissue regeneration, inflammatory responses, fibrosis, and skin tumor development. By examining these aspects, we aim to elucidate the multifaceted roles of THBS1 in clinically refractory skin diseases and its translational potential as a therapeutic target.

P=N/A, N=1800, Recruiting, Mayo Clinic | Trial completion date: Oct 2026 --> Oct 2028 | Trial primary completion date: Oct 2026 --> Oct 2028

This study establishes a 12-gene signature based on PSRGs, which reliably forecasts clinical prognosis in SKCM. The signature captures features of an immune-activated microenvironment, indicating its dual utility for refining risk stratification and predicting benefit from immunotherapy.

Histopathology showed a monomorphic spindle-cell infiltrate without atypia; immunohistochemistry (IHC) confirmed a CD34-positive, S100-negative spindle-cell neoplasm consistent with a myxoid variant of dermatofibrosarcoma protuberans. This case highlights the diagnostic utility of multimodal dermoscopy integrated with histopathology and supportive IHC in precisely evaluating atypical cutaneous tumours.

Bacterial cellulitis was the most common dermatological condition overall, while oral candidiasis was the most common condition in those with advanced HIV infection. Further work is needed to better characterize the profile of skin disease in PLHIV, including in larger prospective cohorts and outpatient settings.

The 2020-2025 period brought meaningful therapeutic advances for CTCL, including new FDA approvals, breakthrough designations, and emergence of cellular therapy. Future development should prioritize patient-reported outcomes as co-primary endpoints, prospective biomarker validation, and combination strategies with non-overlapping toxicity profiles.