^
    18h
    IOV-PED-101: Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants (clinicaltrials.gov)
    P1, N=40, Active, not recruiting, Iovance Biotherapeutics, Inc. | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Amtagvi (lifileucel) • LN-145
    20h
    Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue Sarcoma (clinicaltrials.gov)
    P2, N=20, Suspended, M.D. Anderson Cancer Center | Not yet recruiting --> Suspended
    Trial suspension
    |
    Keytruda (pembrolizumab) • zanzalintinib (XL092)
    24h
    EXTREM ION: Neoadjuvant Irradiation of Extremity Soft Tissue Sarcoma With Ions (clinicaltrials.gov)
    P=N/A, N=42, Recruiting, University Hospital Heidelberg | Trial completion date: Jul 2026 --> Jul 2029 | Trial primary completion date: Jul 2026 --> Jul 2028
    Trial completion date • Trial primary completion date
    1d
    Primary Synovial Sarcoma of the Breast Initially Mimicking Dermatofibrosarcoma Protuberans: A Case Report. (PubMed, Eur J Breast Health)
    Surgical margins were negative, and one-year follow-up showed that the patient remained disease-free. This case highlights the importance of immunohistochemistry and molecular testing for accurate diagnosis and appropriate management.
    Journal
    |
    BCL2 (B-cell CLL/lymphoma 2) • CD34 (CD34 molecule) • SSX1 (SSX Family Member 1)
    1d
    Solitary Fibrous Tumors of the Central Nervous System: A Retrospective Study From a National Referral Hospital in Mexico. (PubMed, Cureus)
    Conclusions Due to their rarity, these tumors may be overlooked in clinical practice. The low availability of diagnostic tests in many centers may contribute to the underestimation of the incidence of SFTs.
    Retrospective data • Journal
    |
    STAT6 (Signal transducer and activator of transcription 6) • NAB2 (NGFI-A Binding Protein 2)
    4d
    Small Round Cell Tumors of Soft Tissue and Skeleton in Children and Youth: A Narrative and TruSight-Based Illustrative Review of Diagnostic Cases. (PubMed, Adv Anat Pathol)
    Immunohistochemistry plays a crucial role in interpreting a specific diagnosis or narrowing the differential diagnosis of SRCTs. Molecular genetic investigations are essential, particularly in cases exhibiting atypical or overlapping histologic and immunohistological features.
    Journal
    |
    BCOR (BCL6 Corepressor) • EWSR1 (EWS RNA Binding Protein 1)
    5d
    NEORASARC: Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall (clinicaltrials.gov)
    P2, N=135, Not yet recruiting, Centre Oscar Lambret
    New P2 trial
    6d
    Highlighting a histopathological dilemma: atypical dermatofibrosarcoma protuberans diagnosed with multimodal dermoscopy. (PubMed, Skin Health Dis)
    Histopathology showed a monomorphic spindle-cell infiltrate without atypia; immunohistochemistry (IHC) confirmed a CD34-positive, S100-negative spindle-cell neoplasm consistent with a myxoid variant of dermatofibrosarcoma protuberans. This case highlights the diagnostic utility of multimodal dermoscopy integrated with histopathology and supportive IHC in precisely evaluating atypical cutaneous tumours.
    Journal
    |
    CD34 (CD34 molecule)
    6d
    Epigenetic remodeling in sarcoma promotes T-cell infiltration via modulation of the Hippo pathway. (PubMed, J Immunother Cancer)
    Our findings reveal an epigenetic-Hippo-immunomodulatory axis in osteosarcoma that also extends to other sarcomas, providing a rationale for incorporating epigenetic preconditioning with immunotherapy to improve patient outcomes and pointing towards novel biomarkers for treatment guidance.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • YAP1 (Yes associated protein 1) • HDAC1 (Histone Deacetylase 1) • ITGAE (Integrin Subunit Alpha E) • VGLL3 (Vestigial Like Family Member 3)
    |
    Jingzhuda (entinostat)
    7d
    Case report: Congenital Bednar tumor with pregnancy-associated growth and pain: a diagnostic pitfall with blue nevus-like features. (PubMed, Front Oncol)
    Immunohistochemistry showed strong CD34 positivity and negative S100 staining, consistent with Bednar tumors. This case highlights the importance of considering Bednar tumors in the differential diagnosis of congenital pigmented lesions, particularly those showing interval growth or symptoms.
    Journal
    |
    CD34 (CD34 molecule)
    7d
    Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients (clinicaltrials.gov)
    P=N/A, N=300, Not yet recruiting, St. Jude Children's Research Hospital
    New trial
    7d
    Compassionate Use of Ubamatamab (clinicaltrials.gov)
    P=N/A, N=0, Available, Regeneron Pharmaceuticals
    New trial
    |
    ubamatamab (REGN4018)