Squamous Cell Carcinoma of Head and Neck

P=N/A, N=30, Recruiting, Tishreen University

Importantly, we constructed a nomogram using PDGFA, age, tumor, and node. Furthermore, high PDGFA expression was associated with HNSCC progression through multiple pathways and processes, suggesting PDGFA as a promising target for therapeutic intervention to modulate anti-tumor responses.

Patients stratified by risk score exhibited distinct immune cell infiltration patterns and drug sensitivity profiles. The EETs-related gene model may serve as a valuable biomarker for predicting prognosis and informing therapeutic strategies in HNSCC patients.

Importantly, irofulven and ferroptosis inducer RSL3 exerted significant synergistic effects on HNSCC in vitro and in vivo. Altogether, this study offers a potential strategy for developing a combination therapy for targeting ferroptosis in the treatment of HNSCC.

P1, N=30, Not yet recruiting, Cancer Institute and Hospital, Chinese Academy of Medical Sciences

P1/2, N=55, Recruiting, University of Chicago | Not yet recruiting --> Recruiting

Finally, we propose a translational framework that integrates standardized detection, localization-aware pathology, multi-omics profiling, organoid and patient-derived xenograft validation, AI-assisted inhibitor discovery, RNA-based delivery, and rational combination therapy. Although no TIPE3-targeted therapies have yet reached clinical application, emerging mechanistic and drug discovery studies underscore TIPE3's potential as a valuable biomarker and therapeutic target in precision oncology.

CDH1 methylation holds promise as a diagnostic biomarker for HNC, demonstrating high specificity but moderate sensitivity. While its association with specific clinicopathological factors is notable, it should be used in conjunction with other diagnostic tools for more effective clinical application.

This study demonstrates a high prevalence of HPV, predominantly HPV-16, in oropharyngeal carcinomas compared with other head and neck sites in our cohort. These results provide baseline data for Colombia and highlight the need for multicenter studies including more heterogeneous populations to guide future prevention and control strategies.

Furthermore, the inhibitory effects of circ_0008777 knockdown on the cell migration and proliferation rates were rescued by c-Myc overexpression. In conclusion, circ_0008777 can promote HNSCC progression by upregulating c-Myc expression through both PC4- and miR-185-3p-related mechanisms, showing potential as a candidate therapeutic target in this cancer.

The SPP1/PLAU dual-gene signature is a robust and independent prognostic biomarker for OPSCC, with particular clinical utility for stratifying high-risk HPV-negative patients.

These genes connect distinct metabolic pathways with specific immune cell subsets, functioning as central hubs within the HNSCC metabolic-immune crosstalk network. Our work provides a critical theoretical basis for future development of lactylation pathway-based biomarkers and targeted interventions.