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    DRUG:

    HyBryte (synthetic hypericin)

    i
    Other names: SGX301
    Associations

    News

    Trials
    Company:
    Soligenix
    Drug class:
    Photosensitizer, Cell death stimulant
    Related drugs:
    Associations

    News

    Trials
    7d
    Emerging Therapeutic Strategies in Cutaneous T-Cell Lymphoma: A Comprehensive Review of Clinical Trials. (PubMed, Am J Clin Dermatol)
    The 2020-2025 period brought meaningful therapeutic advances for CTCL, including new FDA approvals, breakthrough designations, and emergence of cellular therapy. Future development should prioritize patient-reported outcomes as co-primary endpoints, prospective biomarker validation, and combination strategies with non-overlapping toxicity profiles.
    Review • Journal • IO biomarker
    |
    CD70 (CD70 Molecule)
    |
    Copiktra (duvelisib) • tenalisib (RP6530) • Ontak (denileukin diftitox) • Itari (linperlisib) • Lymphir (denileukin diftitox-cxdl) • CTX130 • HyBryte (synthetic hypericin) • lacutamab (IPH4102)
    over1year
    FLASH2: Confirmatory Study of Topical HyBryte™ Vs. Placebo for the Treatment of CTCL (clinicaltrials.gov)
    P3, N=80, Recruiting, Soligenix | Not yet recruiting --> Recruiting
    Enrollment open
    |
    HyBryte (synthetic hypericin)
    almost2years
    HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL (clinicaltrials.gov)
    P2, N=10, Completed, Soligenix | Recruiting --> Completed
    Trial completion
    |
    HyBryte (synthetic hypericin) • Valchlor (mechlorethamine gel)
    almost2years
    FLASH2: Confirmatory Study of Topical HyBryte™ vs. Placebo for the Treatment of CTCL (clinicaltrials.gov)
    P3, N=80, Not yet recruiting, Soligenix
    New P3 trial
    |
    HyBryte (synthetic hypericin)
    over2years
    HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL (clinicaltrials.gov)
    P2, N=10, Recruiting, Soligenix | Not yet recruiting --> Recruiting
    Enrollment open
    |
    HyBryte (synthetic hypericin) • Valchlor (mechlorethamine gel)
    over2years
    HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL (clinicaltrials.gov)
    P2, N=10, Not yet recruiting, Soligenix
    New P2 trial
    |
    HyBryte (synthetic hypericin) • Valchlor (mechlorethamine gel)
    over2years
    Treatment of Mycosis Fungoides With Hypericin Ointment and Visible Light (clinicaltrials.gov)
    P2, N=50, Recruiting, Ellen Kim, MD | Not yet recruiting --> Recruiting
    Enrollment open
    |
    HyBryte (synthetic hypericin)
    almost3years
    Treatment of Mycosis Fungoides With Hypericin Ointment and Visible Light (clinicaltrials.gov)
    P2, N=50, Not yet recruiting, Ellen Kim, MD
    New P2 trial
    |
    HyBryte (synthetic hypericin)