Testicular Cancer

Delayed diagnosis due to occupational neglect allowed the tumor to reach an exceptional size. Although causal associations remain to be established, preventive strategies that reduce exposure to environmental carcinogens, address occupational stress, ensure adequate sleep, and promote routine scrotal self-examination and timely medical consultation may be considered on general health grounds.

Key associations were further supported in validation analyses using GLGC lipid summary statistics. This study provides genetic evidence that lipid-lowering drug targets may have heterogeneous associations with urologic and male reproductive system cancers, supporting long-term pharmacological safety monitoring and further mechanistic and genetic validation.

HAVCR2/TIM-3 expression demonstrates a consistent association with favorable clinical outcomes in seminoma across transcriptomic and protein-level analyses, with a lower risk of progression (HR = 0.201) in the pooled cohort. These exploratory findings support a potential prognostic role of TIM-3 reflecting an immune-active rather than exhausted microenvironment in seminoma, warranting prospective validation.

CD demonstrated promising antioxidant, anti-inflammatory, and anti-apoptotic properties.

P=N/A, N=142, Not yet recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Apr 2029 --> Aug 2029 | Initiation date: Apr 2026 --> Aug 2026 | Trial primary completion date: Apr 2029 --> Aug 2029

It also emphasizes that normal tumor marker levels do not exclude recurrence and that histopathological confirmation remains essential for accurate diagnosis. Recognition of unusual presentations in long-term survivors of germ cell tumors is important to facilitate timely diagnosis and appropriate management.

Our data indicate that DDX53 protein acts as a regulator of RNA metabolism in human cells. Collectively, we show that DDX53 participates in transcriptome regulation (including splicing) in male germ cells and exhibits transcriptomewide RNA interactions, but its wider biological role remains to be clarified.

Platinum-based chemotherapy remains the standard of care in this setting, administered either as conventional-dose cisplatin-based regimens or as high-dose carboplatin-based combination chemotherapy. In this narrative review, we outline established and emerging treatment opportunities for this rare but challenging clinical scenario of platinum-resistant GCCs. This review provides a focused and up-to-date synthesis of therapeutic options for multiply relapsed, platinum-refractory GCCs, with a particular emphasis on late-line treatment sequencing and emerging biomarker-driven strategies, including CLDN6-directed therapies.

A combined model utilising DWI, ADC, T2WI, and contrast-enhanced T1WI imaging, alongside AFP and cystic necrosis, demonstrates high precision, adaptability, and robustness in distinguishing seminoma from non-seminoma testicular tumors.

P2, N=798, Active, not recruiting, National Cancer Institute (NCI) | Trial primary completion date: May 2027 --> May 2026

P1, N=156, Recruiting, Context Therapeutics Inc. | N=80 --> 156 | Trial completion date: Apr 2028 --> Dec 2028 | Trial primary completion date: Apr 2027 --> May 2028

Anti-KLHL11 encephalitis mainly related to infratentorial encephalitis but can also present as limbic encephalitis and rarely as meningitis. Early diagnosis enables early oncological and immunologic treatment, hopefully improving outcomes.