Testicular Cancer

This case report reviews the literature on histologically similar testicular tumors and summarizes diagnostic and management experiences. For testicular mixed germ cell tumors in early adolescence, immediate radical orchiectomy can achieve clinical cure, and long-term follow-up is crucial.

This study highlights the role of CLDN6 in cell adhesion, migration, and proliferation of GCT cells, suggesting that, in addition to its suitability as a therapeutic target, CLDN6 may also play a putative role during tumor progression.

This study highlights PhIP-Seq immunoprofiling to identify serum-based immunosignature panels that can serve as biomarkers for GCTs. This approach addresses the shortcomings of conventional markers and offers a scalable, cost-effective tool for improving cancer diagnosis and management.

Diffuse canine SEM had local invasive features associated with ezrin immunolabelling. According to these findings, PAS staining correlates with canine SEM histomorphology and ezrin immunolabelling can be used as a biological marker of the local invasiveness potential of canine SEMs.

Published cases suggest that IN-TSCT may exhibit aggressive clinical behavior, including metastatic spread in a subset of patients; however, the total number of reported cases remains very limited, and the true metastatic risk and prognostic spectrum have not yet been clearly defined. This review synthesizes the available literature to provide a comprehensive clinicopathologic and molecular overview of this emerging tumor entity.

P=N/A, N=160, Recruiting, Sahlgrenska University Hospital

Intratesticular SBTs are rare Müllerian-type neoplasms that can closely mimic other more aggressive neoplasms. Recognition of their characteristic morphology and immunoprofile, together with emerging molecular insights, is helpful to avoid misdiagnosis and overtreatment.

P2, N=40, Completed, Acousia Therapeutics GmbH | Active, not recruiting --> Completed

In this cohort of 79 adult patients with NF1, 18F-FDG PET/CT proved as a valuable complementary imaging modality to conventional imaging by enabling the detection of incidental malignant or potentially malignant tumors. Our results highlight 18F-FDG PET/CT's beneficial impact on disease management by suggesting that the incorporation of 18F-FDG PET/CT into screening protocols could improve early detection of NF1-related cancers in asymptomatic adults, potentially offering early treatment options to improve clinical outcomes.

P1, N=72, Completed, HiFiBiO Therapeutics | Suspended --> Completed

P2, N=88, Recruiting, Centre Oscar Lambret | Trial completion date: Oct 2029 --> Jul 2032