Testicular Seminoma

Delayed diagnosis due to occupational neglect allowed the tumor to reach an exceptional size. Although causal associations remain to be established, preventive strategies that reduce exposure to environmental carcinogens, address occupational stress, ensure adequate sleep, and promote routine scrotal self-examination and timely medical consultation may be considered on general health grounds.

HAVCR2/TIM-3 expression demonstrates a consistent association with favorable clinical outcomes in seminoma across transcriptomic and protein-level analyses, with a lower risk of progression (HR = 0.201) in the pooled cohort. These exploratory findings support a potential prognostic role of TIM-3 reflecting an immune-active rather than exhausted microenvironment in seminoma, warranting prospective validation.

It also emphasizes that normal tumor marker levels do not exclude recurrence and that histopathological confirmation remains essential for accurate diagnosis. Recognition of unusual presentations in long-term survivors of germ cell tumors is important to facilitate timely diagnosis and appropriate management.

Our data indicate that DDX53 protein acts as a regulator of RNA metabolism in human cells. Collectively, we show that DDX53 participates in transcriptome regulation (including splicing) in male germ cells and exhibits transcriptomewide RNA interactions, but its wider biological role remains to be clarified.

A combined model utilising DWI, ADC, T2WI, and contrast-enhanced T1WI imaging, alongside AFP and cystic necrosis, demonstrates high precision, adaptability, and robustness in distinguishing seminoma from non-seminoma testicular tumors.

P2, N=798, Active, not recruiting, National Cancer Institute (NCI) | Trial primary completion date: May 2027 --> May 2026

Anti-KLHL11 encephalitis mainly related to infratentorial encephalitis but can also present as limbic encephalitis and rarely as meningitis. Early diagnosis enables early oncological and immunologic treatment, hopefully improving outcomes.

Our findings for the first time identify primate-specific RBMXL3 protein as a new upstream regulator of RNA metabolism, characterized by broad RNA-binding activity in human TCam-2 cells. Finally, we show that RBMXL3 expression heavily reduces LINE-1 retrotransposition in human cells, underlying RBMXL3 importance in maintaining genome integrity. Our data suggest that RBMXL3 may contribute to the regulation of transcriptome dynamics in male germ cells, while its broader functional implications remain to be determined.

P=N/A, N=55, Active, not recruiting, University of Southern California | Trial completion date: Aug 2027 --> Dec 2027 | Trial primary completion date: Aug 2026 --> Dec 2026

Histopathology confirmed classical seminoma, staged as pT1b. This case highlights that long standing hydrocele with atypical features may conceal testicular malignancy, and early ultrasonography with tumor marker assessment is essential for timely diagnosis.

P=N/A, N=20, Not yet recruiting, Istituto Clinico Humanitas

It is concluded, that GPX2 expression is common in cancer and preferably occurs in tumor entities derived from normal cell types with high GPX2 expression. In these tumors, reduced GPX2 expression is often linked to features of aggressive disease.