^
    19h
    MAPS: Molecular Analysis for Precision Surgery in Thyroid Cancer Trial (clinicaltrials.gov)
    P=N/A, N=2, Completed, University of California, Los Angeles | Recruiting --> Completed | N=125 --> 2
    Trial completion • Enrollment change
    |
    BRAF (B-raf proto-oncogene)
    1d
    Sky-High Thyroglobulin Level Following Thyroid Lobectomy Without Evidence of Metastatic Disease. (PubMed, AACE Endocrinol Diabetes)
    Measuring Tg and Tg antibody levels post-TL can provide a baseline for future reference. However, this case illustrates that high levels of Tg can be seen in the absence of thyroid cancer and therefore cannot reliably predict the risk of recurrence.
    Journal
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    TG (Thyroglobulin)
    1d
    Differentiated thyroid carcinoma in children and adolescents (PubMed, Probl Endokrinol (Mosk))
    Differentiated thyroid carcinoma in children is characterized by a number of clinical and molecular genetic features, which determines the need for a specialized multidisciplinary approach to their management. The high risk of malignancy in nodules, frequent regional dissemination and peculiarities of the molecular profile argue for the necessity of early diagnosis, integration of molecular testing and personalized choice of the volume of surgical intervention in the conditions of specialized centers.
    Retrospective data • Journal
    |
    PTEN (Phosphatase and tensin homolog) • APC (APC Regulator Of WNT Signaling Pathway) • DICER1 (Dicer 1 Ribonuclease III)
    2d
    ANAPLASTIC THYROID CARCINOMA DEVELOPED YEARS AFTER THE PATIENT HAD UNDERGONE PARTIAL THYROIDECTOMY DUE TO PAPILLARY THYROID CARCINOMA. (PubMed, Acta Clin Croat)
    In conclusion, when surgical near-total thyroidectomy is performed in patients with papillary thyroid carcinoma, a new malignancy may develop in the residual thyroid tissue even after many years. In such cases, completion total thyroidectomy and adjuvant multimodal treatment methods should be preferred.
    Journal
    |
    ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
    3d
    Single-cell analysis identifies ATC-like cells driving progression in relapsed follicular thyroid carcinoma. (PubMed, Endocrinology)
    This reveals a previously unrecognized population of ATC-like cells in RFTC marked by high UBE2C expression. UBE2C contributes to FTC progression by enhancing proliferation and modulating key metabolic pathways, suggesting it as both a critical biomarker of aggressive disease and a potential therapeutic target.
    Journal
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    UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    4d
    Ruminococcaceae promotes the NLRP3/ASC/Caspase-1 axis-mediated pyroptotic signaling in papillary thyroid carcinoma by upregulating RBM15 to increase the N6-methyladenosine methylation modulation of NLRP3. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
    In addition, knocking down RBM15 effectively reversed the effects of Rum mentioned above in vivo and in vitro. Mechanistically, Rum activates the NLRP3/ASC/Caspase-1 axis-mediated pyroptotic signaling in PTC by upregulating RBM15 to increase the N6-methyladenosine methylation modulation of NLRP3, thereby providing a novel strategy and target for the clinical treatment of PTC.
    Journal
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    IFNG (Interferon, gamma) • MMP2 (Matrix metallopeptidase 2) • IL18 (Interleukin 18) • MMP9 (Matrix metallopeptidase 9) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • RBM15 (RNA Binding Motif Protein 15)
    6d
    A Retrospective Study on the Effect of TSH Suppression Therapy on Volume Reduction of Papillary Thyroid Microcarcinoma Following Ablation (ChiCTR2600117007)
    P=N/A, N=600, Not yet recruiting, Shanghai Ninth People's Hospital， Shanghai JiaoTong University School of Medicine; Shanghai Ninth People's Hospital， Shanghai JiaoTong University
    New trial
    6d
    Efficacy and Prognosis of Microwave Ablation Treatment for Papillary Thyroid Microcarcinoma Assessed by Contrast-Enhanced Ultrasound Combined with Genetic and Molecular Diagnostics: A Prospective Observational Study (ChiCTR2600116115)
    P=N/A, N=0, Not yet recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    New trial
    6d
    Interpretable AI Model Based on Radiogenomics for Early Intelligent Prediction of Radioactive Iodine-Refractory Differentiated Thyroid Cancer (ChiCTR2500115573)
    P=N/A, N=1000, Not yet recruiting, Zhejiang Cancer Hospital; Zhejiang Cancer Hospital
    New trial
    6d
    Mechanistic Study of Lymph Node Metastasis in Papillary Thyroid Carcinoma Based on Multimodal Ultrasound Fusion and Explainable Artificial Intelligence (ChiCTR2500115271)
    P=N/A, N=1100, Not yet recruiting, Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital); Guangdong Second Provincial General Hospital (Guangdong Provin
    New trial
    6d
    The Impact of Proactive Nursing on Quality of Life in Thyroid Cancer Patients Post-Radical Surgery (ChiCTR2500115206)
    P=N/A, N=228, Completed, Fujian Province Cancer Hospital; Fujian Province Cancer Hospital
    New trial