Tongue Carcinoma

SNHG26 depletion reversed NK cell suppression and cisplatin resistance in vitro and in vivo. Thus, our study identifies exosomal SNHG26 as a key mediator of cisplatin resistance and NK cell dysfunction in TSCC, suggesting its potential as a promising therapeutic target.

The findings confirm MMP-14 overexpression in OSCC and its association with perineural invasion, underscoring its role in tumor progression. No significant correlations were found with lymph node metastasis, clinical stage, or histological grade. Limitations include MMP-14's ubiquitous expression, reducing biomarker specificity. Further research incorporating additional molecular markers is warranted to refine prognostic accuracy.

A multidisciplinary approach combining radical surgery and adjuvant RT is crucial; however, the rapid distant progression highlights the critical need for more effective systemic treatment options and the integration of genetic profiling to guide personalized therapies. Further comprehensive research is essential to optimize management strategies and improve the limited survival outcomes associated with this rare and challenging malignancy.

At the last follow-up in August 2025, the patient had a progression-free survival (PFS) of 29.8 months, with no evidence of recurrence in the lung lesions. This case demonstrates the efficacy of a multimodal induction chemoimmunotherapy in achieving complete response and preserving organ function, thereby providing a promising therapeutic option for patients with synchronous lung and base-of-tongue SCC.

This interplay observed between cancer cells, neurons, and glial cells suggests a potential mechanism through which tumor-associated nerves might influence cancer stemness via metabolic reprogramming. This highlights a possible direction for anticancer therapy that warrants further investigation.

The clinical manifestations and pathological examination of the three cases were consistent with the characteristics of highly differentiated squamous cell carcinoma. Additionally, immunohistochemical analysis revealed positive expression of p63, CK5/6, p40, CK19, CK7, and CK20. In three cases, the results of human papillomavirus were negative. This study provides an important reference for the diagnosis of TSCC in rhesus monkeys.

The major conclusion of this study is that overall LVD is an indicator of aggressiveness of TSCC and a negative prognostic factor strongly associated with nodal metastasis. LVD assessment can improve risk stratification and lead to personalized treatment approaches in TSCC management.

MMP9, which originates from activated satellite glial cells in the TG, post-SCC inoculation, contributes to tongue-cancer-associated pain.

We conclude that adipocytes increase the proliferation of cancer cells and enhance their motility without direct cell contact. The protumourigenic effect of adipocytes is likely mediated by secreted cytokines, such as IL-6, and transported via EVs.

Critically, pharmacological inhibition of MTHFD2 (e.g., DS18561882) blocks FOXO1 degradation, establishing the MTHFD2-FOXO1 axis as a promising therapeutic target for TSCC through its novel metabolic-epigenetic regulatory mechanism. Implications: This study identifies the MTHFD2-FOXO1 axis as a druggable metabolic-epigenetic pathway in TSCC, providing both a prognostic marker and a therapeutic target.

Vitamin D represents an efficient anticancer adjuvant that permits a novel therapeutic strategy for cancer patients.

This case highlights the diagnostic challenges of differentiating LLTs from spindle cell lipomas (SCLs), particularly in the context of pRB deficiency and RB1 deletion. This case exemplifies the molecular heterogeneity of neoplasms with lipoblastoma-like features.