Uterine Cancer

P3, N=348, Active, not recruiting, Tata Memorial Hospital | Trial completion date: Jan 2026 --> Apr 2026

Both HER2 IHC positive (3+) and FISH positive occur exclusively in pure USC tumors. HER2 gene amplification can be observed in any HER2 IHC levels.

This case uniquely highlights the importance of comprehensive tumour marker assessment, the role of marker-guided surveillance in early relapse detection, and demonstrates the feasibility of successful salvage therapy. The case expands current knowledge of extragonadal YST management, encourages vigilance for atypical presentations and underscores the value of individualised multimodality care-even in aggressive, relapsed disease-for achieving complete remission.

Overall, Gouania longipetala aqueous extract exhibit selective activity on estradiol-sensitive tissues in vivo and, various effects against breast cancer cell proliferation and estradiol-induced proliferative effects in vitro. All taken into account, GLO may have a notably importance as therapeutic agent used in chemotherapy against E2-dependent cancer.

P2/3, N=73, Active, not recruiting, National Cancer Institute (NCI) | N=190 --> 73 | Trial completion date: Mar 2030 --> Jan 2027

Beyond histological grade, proliferative signaling and M2 macrophage polarization strongly influence recurrence risk in ESS. These findings highlight potential diagnostic and therapeutic targets, suggesting integration of immune and cell-cycle biomarkers into future risk stratification models.

P=N/A, N=600, Not yet recruiting, Asan Medical Center

Nicotinamide metabolism was found to be significantly linked with EC progression. This study offers new perceptions into the role of nicotinamide metabolism in EC and suggests possible avenues for treatment advancements.

In this context, the CAP regimen-comprising cyclophosphamide, adriamycin, and cisplatin-has demonstrated superior overall efficacy. Moreover, these tumors seem to be relatively resistant to radiation therapy.

Laparoscopic total hysterectomy with bilateral salpingo-oophorectomy was performed uneventfully, and at 7 months she remains disease-free. The case underlines that adenosarcoma can masquerade as cervical cancer, emphasises the need for generous tissue sampling and WT1/ER-based immunohistochemistry to define tumour origin, and confirms excellent outcomes with complete surgical excision for stage I disease.

P=N/A, N=134, Not yet recruiting, Xuzhou Central Hospital; Xuzhou Central Hospital

P=N/A, N=316, Completed, Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Sun Yat-sen Memorial Hospital, Sun Yat-sen University