The DecisionDx-UMSeq test is a 7-gene panel that uses next-generation sequencing (NGS) to identify somatic mutations relevant to UM. The test includes hotspot mutations in the genes GNAQ, GNA11, CYSLTR2, PLCB4, and SF3B1, mutations in exons 1-2 of EIF1AX, and all coding exons of the BAP1 gene.
Cancer:
Uveal Melanoma
Gene:
BAP1 (BRCA1 Associated Protein 1), CYSLTR2 (Cysteinyl Leukotriene Receptor 2), EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked), GNA11 (G Protein Subunit Alpha 11), GNAQ (G Protein Subunit Alpha Q), Other genes
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BAP1 (BRCA1 Associated Protein 1), CYSLTR2 (Cysteinyl Leukotriene Receptor 2), EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked), GNA11 (G Protein Subunit Alpha 11), GNAQ (G Protein Subunit Alpha Q), Other genes, PLCB4 (Phospholipase C Beta 4), SF3B1 (Splicing Factor 3b Subunit 1)