TEST:

MammaPrint®

P1, N=32, Active, not recruiting, Patrick Dillon, MD | Recruiting --> Active, not recruiting

P=N/A, N=750, Completed, Novartis Pharmaceuticals

P=N/A, N=22, Completed, Universitair Ziekenhuis Brussel | Recruiting --> Completed

Approximately one-third of patients who met GEP criteria and were eligible for publicly known reimbursement received a GEP. Appropriate follow-up steps and further research seem required to analyse reasons for not ordering a GEP in times of reimbursement, since GEP results help chemotherapy decision-making.

We established a low-ITH subtyping framework that overcomes the limitations of single-biopsy-based molecular typing. Our findings offer a novel strategy to enhance the precision of breast cancer management.

P3, N=3680, Recruiting, National Cancer Institute (NCI) | Trial completion date: May 2027 --> May 2032 | Trial primary completion date: May 2027 --> May 2032

BRIDGE is a biologically grounded framework for neoadjuvant BC response prediction, validated on a rich set of different patients' cohorts. Its histopathology-based version opens the door for fast and low-cost prediction in the neoadjuvant setting, upon further prospective testing and validation.

P2, N=44, Recruiting, Abramson Cancer Center at Penn Medicine | N=66 --> 44

Although evaluated in breast cancer, CNet-Cox is readily extensible to other diseases, molecular interaction networks and time-to-event endpoints, providing a generalizable tool for digital pathology and precision oncology. Overall, our comprehensive downstream analyses highlight that CNet-Cox offers a novel network-aware survival model for systematically discovering connected biomarkers and delivering scalable, precise and interpretable risk prediction.

"Agendia®, Inc...today announced new data to be presented at the 2026 American Society of Clinical Oncology (ASCO®) Annual Meeting, taking place May 29 – June 2 in Chicago. The company will present two posters highlighting how MammaPrint® (MP) + BluePrint® (BP) provide biological insights into treatment response and help further refine therapeutic decision-making for patients with early-stage breast cancer (EBC)."

Furthermore, Sig27 and Sig27IM predicted pathologic complete response in BC treated with PD1 and PD-L1 inhibitors; Sig27IM displayed robust correlations with established immune-signatures: CTL, Merck18, TIDE, and STAT1_sig. Collectively, Sig27 captures BC's immune properties, which likely contribute to its biomarker potential.

For ER+/HER2- early breast cancer, the utility of genomic assays such as Oncotype DX, PAM50, and MammaPrint is discussed, with a focus on chemotherapy selection and the role of CDK4/6 inhibitors, and the role of extended endocrine therapy and adjuvant zoledronic acid. In HER2-positive breast cancer, we examine neoadjuvant therapy with dual HER2 blockade (trastuzumab and pertuzumab), personalized regimens that minimize cardiotoxicity, and the potential of antibody-drug conjugates. For TNBC, the growing role of immunotherapy, dose-dense regimens, and adjuvant capecitabine is reviewed, with a focus on olaparib in BRCA-mutated cases. This review also addresses special populations, including BRCA mutation carriers and premenopausal women, and looks at future trends in systemic therapy, including novel agents, biomarker-driven approaches, and treatment de-escalation strategies.